SCHEMBL20539129

SCHEMBL20539129

c1ccc2c(c1)Sc1ccccc1[Si]21c2ccccc2Sc2ccccc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 6/20 0.42
NOX1 Q9Y5S8 5/20 0.42
ACHE P22303 5/20 0.42
GAA P10253 3/20 0.42
MAPT P10636 3/20 0.42
MAOA P21397 2/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
CYP1A2 P05177 1/20 0.42
POLB P06746 1/20 0.42
CYP3A4 P08684 1/20 0.42
ADORA3 P0DMS8 1/20 0.42
ALOX15 P16050 1/20 0.42
ALOX12 P18054 1/20 0.42
CNR1 P21554 1/20 0.42
PTGS1 P23219 1/20 0.42
SLC6A2 P23975 1/20 0.42
HTR2C P28335 1/20 0.42
PTGS2 P35354 1/20 0.42
SNCA P37840 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30996985 0.90 ALDH1A1 (0.39) BCHENOX1ACHEGAAMAPT
SCHEMBL11990885 0.90 ALDH1A1 (0.39) BCHENOX1ACHEGAAMAPT
SCHEMBL20561628 0.85 BCHE (0.36) BCHENOX1ACHEGAAMAPT
SCHEMBL30996977 0.79 ALDH1A1 (0.33) ALDH1A1KDM4EHPGDL3MBTL1
SCHEMBL22472525 0.79 ALDH1A1 (0.41) GAAMAPTMEN1KMT2AALOX15
SCHEMBL30996974 0.79 ALDH1A1 (0.33) ALDH1A1KDM4EHPGDL3MBTL1
SCHEMBL24140672 0.78 HDAC6 (0.40) BCHENOX1ACHEGAAMAPT
SCHEMBL20539745 0.78 MAOA (0.41) BCHENOX1ACHEGAAMAPT
SCHEMBL24644210 0.78 BCHE (0.39) BCHENOX1ACHEGAAMAPT
SCHEMBL31643923 0.78 BCHE (0.39) BCHENOX1ACHEGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180309067-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION 2018-10-25 US claimed
US-11038137-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2021-06-15 US disclosed
US-10790455-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2020-09-29 US disclosed
US-20180309067-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION 2018-10-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180309067-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES ORC3, EZH1, BMI1 BCHE 2453/4885NOX1 1451/4885ACHE 634/4885
US-10790455-B2 Organic electroluminescent materials and devices ORC3, ALKBH2, ENPP3 BCHE 2093/4885NOX1 1666/4885ACHE 440/4885
US-11038137-B2 Organic electroluminescent materials and devices ORC3, NUDC, AOC1 BCHE 1265/4885NOX1 1675/4885ACHE 994/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.