Sugi Predict

Sugi Predict / Compounds / SCHEMBL20540359

SCHEMBL20540359

SCHEMBL20540359

CC1(C)OB(c2ccc(OCCO[Si](C)(C)C(C)(C)C)cc2)OC1(C)C

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 1/20 0.43
▸ CA2 P00918 1/20 0.43
▸ CA9 Q16790 1/20 0.43
▸ AAK1 Q2M2I8 1/20 0.42
▸ DGAT1 O75907 2/20 0.42
▸ LPL P06858 10/20 0.41
▸ LIPG Q9Y5X9 10/20 0.41
▸ HIF1A Q16665 2/20 0.39
▸ SNCA P37840 1/20 0.37
▸ F11 P03951 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20841744 0.93 CA1 (0.43) CA1CA2CA9AAK1DGAT1
SCHEMBL20841728 0.93 CA1 (0.43) CA1CA2CA9AAK1DGAT1
SCHEMBL20841763 0.92 LPL (0.42) CA1CA2CA9AAK1DGAT1
SCHEMBL427591 0.85 CA1 (0.56) CA1CA2CA9AAK1DGAT1
SCHEMBL23036098 0.85 AAK1 (0.41) CA1CA2CA9AAK1DGAT1
SCHEMBL1284293 0.84 LPL (0.40) CA1CA2CA9AAK1DGAT1
SCHEMBL10249044 0.83 DGAT1 (0.56) CA1CA2CA9AAK1DGAT1
SCHEMBL2823682 0.82 LIPG (0.56) CA1CA2CA9DGAT1LPL
SCHEMBL25623835 0.82 AAK1 (0.36) AAK1DGAT1HIF1A
SCHEMBL19263486 0.81 CA1 (0.42) CA1CA2CA9AAK1DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12590062-B2 PD-1/PD-L1 inhibitors GILEAD SCIENCES, INC. (US) 2026-03-31 — — US disclosed
US-20250026766-A1 Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors BEIGENE, LTD. (KY) 2025-01-23 — — US disclosed
EP-4463456-A1 THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS BeiGene, Ltd. (KY) 2024-11-20 — — EP disclosed
WO-2023134708-A1 THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS BEIGENE , LTD. (KY) 2023-07-20 — — WO disclosed
EP-4026835-A2 PD-1/PD-L1 INHIBITORS Gilead Sciences, Inc. (US) 2022-07-13 — — EP disclosed
EP-3612525-B1 PD-1/PD-L1 INHIBITORS GILEAD SCIENCES INC (US) 2021-10-27 — — EP disclosed
US-20210323922-A1 PD-1/PD-L1 INHIBITORS GILEAD SCIENCES, INC. (US) 2021-10-21 — — US disclosed
US-20210323922-A1 PD-1/PD-L1 INHIBITORS GILEAD SCIENCES, INC. (US) 2021-10-21 — — US disclosed
US-10239884-B2 Coelenterazine compounds and uses thereof KEIO UNIVERSITY (JP) 2019-03-26 — — US disclosed
US-20180305315-A1 PD-1/PD-L1 INHIBITORS GILEAD SCIENCES, INC. 2018-10-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210323922-A1 PD-1/PD-L1 INHIBITORS CD274, PDCD1, PDCD1LG2 CA1 2682/4885CA2 3721/4885CA9 719/4885
US-10239884-B2 Coelenterazine compounds and uses thereof CTRC, GLB1, GALC CA1 3867/4885CA2 2974/4885CA9 2966/4885
US-12590062-B2 PD-1/PD-L1 inhibitors CD274, PDCD1LG2, PDCD1 CA1 2733/4885CA2 3359/4885CA9 526/4885
US-20250026766-A1 Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors POLQ, POLK, POLI CA1 3117/4885CA2 3068/4885CA9 3096/4885
US-20180305315-A1 PD-1/PD-L1 INHIBITORS CD274, PDCD1, PDCD1LG2 CA1 2682/4885CA2 3721/4885CA9 719/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.