Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.37 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | NNMT | P40261 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11191706 | 0.84 | — | — | |
| SCHEMBL20544622 | 0.83 | LMNA (0.41) | LMNAFDPSUSP2NNMTCYP2C19 | |
| Iodide SCHEMBL4221259 | 0.82 | FDPS (0.49) | LMNAFDPSUSP2NNMTCYP2C19 | |
| SCHEMBL11689059 | 0.77 | USP2 (0.42) | LMNAUSP2NNMTBCHEGLA | |
| SCHEMBL23004446 | 0.77 | FUT7 (0.47) | LMNACA2 | |
| SCHEMBL20544415 | 0.76 | BCHE (0.37) | LMNAFDPSUSP2NNMTBCHE | |
| SCHEMBL20544696 | 0.76 | USP2 (0.41) | LMNAUSP2NNMTBCHEGLA | |
| SCHEMBL11692088 | 0.76 | HDAC8 (0.68) | LMNAUSP2NNMTBCHEGLA | |
| Trigonelline SCHEMBL11786615 | 0.75 | USP2 (0.57) | LMNAUSP2NNMTBCHEGLA | |
| SCHEMBL2779790 | 0.73 | HDAC8 (0.49) | LMNAUSP2NNMTBCHEGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12398104-B2 | Odorless thiols for permanent waving, straightening and depilatory applications | THE PROCTER & GAMBLE COMPANY (US) | 2025-08-26 | — | — | US | disclosed |
| CN-110573137-B | Odorless thiols for permanent wave, straightening and dehairing applications | 宝洁公司 | 2023-08-18 | — | — | CN | disclosed |
| EP-3614999-B1 | ODORLESS THIOLS FOR PERMANENT WAVING, STRAIGHTENING AND DEPILATORY APPLICATIONS | PROCTER & GAMBLE (US) | 2022-07-13 | — | — | EP | disclosed |
| CN-110573137-A | Odorless thiols for long lasting wave, straightening and depilatory applications | 宝洁公司 | 2019-12-13 | — | — | CN | disclosed |
| US-20180311134-A1 | ODORLESS THIOLS FOR PERMANENT WAVING, STRAIGHTENING AND DEPILATORY APPLICATIONS | THE PROCTER & GAMBLE COMPANY | 2018-11-01 | — | — | US | disclosed |
| US-20180312468-A1 | ODORLESS THIOLS FOR PERMANENT WAVING, STRAIGHTENING AND DEPILATORY APPLICATIONS | THE PROCTER & GAMBLE COMPANY | 2018-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312468-A1 | ODORLESS THIOLS FOR PERMANENT WAVING, STRAIGHTENING AND DEPILATORY APPLICATIONS | TST, TMT1A, PTMS | ACHE 594/4885CHRM1 3085/4885CHRM3 2899/4885 |
| US-12398104-B2 | Odorless thiols for permanent waving, straightening and depilatory applications | TST, TMT1A, PTMS | ACHE 594/4885CHRM1 3085/4885CHRM3 2899/4885 |
| US-20180311134-A1 | ODORLESS THIOLS FOR PERMANENT WAVING, STRAIGHTENING AND DEPILATORY APPLICATIONS | PLPBP, DAO, TST | ACHE 2760/4885CHRM1 2861/4885CHRM3 2299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.