Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.38 |
| ▸ | NNMT | P40261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | BCHE | P06276 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10256983 | 0.82 | — | — | |
| SCHEMBL11689059 | 0.80 | USP2 (0.42) | USP2HDAC8NNMTLMNABCHE | |
| SCHEMBL11692088 | 0.79 | HDAC8 (0.68) | USP2HDAC8NNMTLMNABCHE | |
| SCHEMBL20544622 | 0.76 | LMNA (0.41) | USP2HDAC8NNMTLMNABCHE | |
| SCHEMBL20544692 | 0.76 | LMNA (0.44) | USP2HDAC8NNMTLMNABCHE | |
| SCHEMBL2779790 | 0.76 | HDAC8 (0.49) | USP2HDAC8NNMTLMNABCHE | |
| SCHEMBL5485440 | 0.75 | HDAC8 (0.71) | USP2HDAC8NNMTLMNABCHE | |
| Trigonelline SCHEMBL11786615 | 0.75 | USP2 (0.57) | USP2HDAC8NNMTLMNABCHE | |
| SCHEMBL28349758 | 0.74 | RAD52 (0.37) | USP2LMNANPSR1RAD52KDM4E | |
| SCHEMBL398916 | 0.74 | RAD52 (0.37) | USP2LMNANPSR1RAD52KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12398104-B2 | Odorless thiols for permanent waving, straightening and depilatory applications | THE PROCTER & GAMBLE COMPANY (US) | 2025-08-26 | — | — | US | disclosed |
| CN-110573137-B | Odorless thiols for permanent wave, straightening and dehairing applications | 宝洁公司 | 2023-08-18 | — | — | CN | disclosed |
| EP-3614999-B1 | ODORLESS THIOLS FOR PERMANENT WAVING, STRAIGHTENING AND DEPILATORY APPLICATIONS | PROCTER & GAMBLE (US) | 2022-07-13 | — | — | EP | disclosed |
| EP-3614999-A1 | ODORLESS THIOLS FOR PERMANENT WAVING, STRAIGHTENING AND DEPILATORY APPLICATIONS | The Procter and Gamble Company (US) | 2020-03-04 | — | — | EP | disclosed |
| CN-110573137-A | Odorless thiols for long lasting wave, straightening and depilatory applications | 宝洁公司 | 2019-12-13 | — | — | CN | disclosed |
| US-20180311134-A1 | ODORLESS THIOLS FOR PERMANENT WAVING, STRAIGHTENING AND DEPILATORY APPLICATIONS | THE PROCTER & GAMBLE COMPANY | 2018-11-01 | — | — | US | disclosed |
| US-20180312468-A1 | ODORLESS THIOLS FOR PERMANENT WAVING, STRAIGHTENING AND DEPILATORY APPLICATIONS | THE PROCTER & GAMBLE COMPANY | 2018-11-01 | — | — | US | disclosed |
| WO-2018200772-A1 | ODORLESS THIOLS FOR PERMANENT WAVING, STRAIGHTENING AND DEPILATORY APPLICATIONS | THE PROCTER & GAMBLE COMPANY (US) | 2018-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312468-A1 | ODORLESS THIOLS FOR PERMANENT WAVING, STRAIGHTENING AND DEPILATORY APPLICATIONS | TST, TMT1A, PTMS | ACHE 594/4885USP2 450/4885HDAC8 680/4885 |
| US-12398104-B2 | Odorless thiols for permanent waving, straightening and depilatory applications | TST, TMT1A, PTMS | ACHE 594/4885USP2 450/4885HDAC8 680/4885 |
| US-20180311134-A1 | ODORLESS THIOLS FOR PERMANENT WAVING, STRAIGHTENING AND DEPILATORY APPLICATIONS | PLPBP, DAO, TST | ACHE 2760/4885USP2 1266/4885HDAC8 3201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.