Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20546709 | 0.91 | LMNA (0.51) | SMN1; SMN2CYP1A2CYP2C19HTTCYP2D6 | |
| SCHEMBL20547217 | 0.89 | LMNA (0.47) | SMN1; SMN2CYP1A2CYP2C19HTTCYP2D6 | |
| SCHEMBL20547218 | 0.88 | KMT2A (0.51) | MAPTLMNATSHRALDH1A1KMT2A | |
| SCHEMBL20547285 | 0.87 | KCNH2 (0.56) | SMN1; SMN2CYP1A2CYP2C19HTTCYP2D6 | |
| SCHEMBL20547246 | 0.82 | NPC1 (0.53) | SMN1; SMN2MAPTLMNATSHRHRH1 | |
| SCHEMBL20547359 | 0.82 | DPP4 (0.48) | SMN1; SMN2CYP1A2MAPTLMNATSHR | |
| SCHEMBL20547288 | 0.81 | LMNA (0.50) | SMN1; SMN2HTTMAPTLMNATSHR | |
| SCHEMBL20547293 | 0.80 | NPC1 (0.54) | SMN1; SMN2MAPTLMNATSHRHRH1 | |
| SCHEMBL20547245 | 0.78 | NPC1 (0.53) | SMN1; SMN2CYP1A2CYP2C19CYP2C9MAPT | |
| SCHEMBL11832459 | 0.70 | SMYD3 (0.53) | SMN1; SMN2CYP1A2CYP2C19CYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3560927-B1 | AZEPINE DERIVATIVES ACTING AS 5-HT7 RECEPTOR MODULATORS | KOREA INST SCI & TECH (KR) | 2023-04-19 | — | — | EP | disclosed |
| EP-3560927-A1 | AZEPINE DERIVATIVE ACTING AS 5-HT7 RECEPTOR MODULATOR | Korea Institute of Science and Technology (KR) | 2019-10-30 | — | — | EP | disclosed |
| US-10435408-B2 | Azepine derivatives as 5-HT7 receptor modulators | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2019-10-08 | — | — | US | disclosed |
| US-20180312509-A1 | AZEPINE DERIVATIVES AS 5-HT7 RECEPTOR MODULATORS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2018-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312509-A1 | AZEPINE DERIVATIVES AS 5-HT7 RECEPTOR MODULATORS | HTR7, HTR5A, HTR3A | SMN1; SMN2 433/4885CYP1A2 586/4885CYP2C19 187/4885 |
| US-10435408-B2 | Azepine derivatives as 5-HT7 receptor modulators | HTR7, HTR5A, HTR3A | SMN1; SMN2 433/4885CYP1A2 586/4885CYP2C19 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.