Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22229495 | 0.68 | ALDH1A1 (0.42) | ALDH1A1HPGDHSD17B10MAPTKDM4E | |
| SCHEMBL20550657 | 0.68 | ALDH1A1 (0.42) | ALDH1A1HPGDHSD17B10MAPTKDM4E | |
| SCHEMBL11775855 | 0.67 | LMNA (0.52) | ALDH1A1TLR8NR1I2AHRLMNA | |
| SCHEMBL30696400 | 0.67 | LMNA (0.52) | ALDH1A1TLR8NR1I2AHRLMNA | |
| SCHEMBL29444102 | 0.65 | MAPT (1.00) | ALDH1A1HPGDHSD17B10MAPTKDM4E | |
| SCHEMBL503252 | 0.65 | MAPT (1.00) | ALDH1A1HPGDHSD17B10MAPTKDM4E | |
| SCHEMBL30939014 | 0.63 | ALDH1A1 (0.67) | ALDH1A1HPGDHSD17B10MAPTKDM4E | |
| SCHEMBL12543710 | 0.63 | ALDH1A1 (0.67) | ALDH1A1HPGDHSD17B10MAPTKDM4E | |
| SCHEMBL4597901 | 0.62 | LMNA (0.42) | ALDH1A1NR1I2AHRLMNAMEN1 | |
| SCHEMBL11668050 | 0.60 | MAOA (0.59) | ALDH1A1HPGDHSD17B10MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200231607-A1 | TRISUBSTITUTEDSILYLHETEROARYLOXYQUINOLINES AND ANALOGUES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-07-23 | — | — | US | disclosed |
| EP-3618632-A1 | TRISUBSTITUTEDSILYLHETEROARYLOXYQUINOLINES AND ANALOGUES | Bayer Aktiengesellschaft (DE) | 2020-03-11 | — | — | EP | disclosed |
| WO-2018202706-A1 | TRISUBSTITUTEDSILYLHETEROARYLOXYQUINOLINES AND ANALOGUES | BAYER AKTIENGESELLSCHAFT (DE) | 2018-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200231607-A1 | TRISUBSTITUTEDSILYLHETEROARYLOXYQUINOLINES AND ANALOGUES | PIK3C3, ERG28, DDT | ALDH1A1 3448/4885HPGD 3577/4885HSD17B10 2000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.