Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.52 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.52 |
| ▸ | GABRP | O00591 | 1/20 | 0.52 |
| ▸ | GABRD | O14764 | 1/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.52 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.52 |
| ▸ | GABRE | P78334 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.52 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.52 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.52 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15367664 | 0.86 | — | — | |
| SCHEMBL3645869 | 0.82 | — | — | |
| SCHEMBL3997244 | 0.80 | GABRA1 (0.56) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL9427736 | 0.78 | GABRA1 (0.54) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL1026427 | 0.77 | — | — | |
| SCHEMBL5317263 | 0.77 | — | — | |
| SCHEMBL523784 | 0.76 | GABRA1 (0.52) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL15027501 | 0.76 | TSHR (0.52) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL5163 | 0.76 | GABRP (0.52) | GABRA1TSHRGABRG2GABRB3GABRA5 | |
| SCHEMBL11122728 | 0.76 | GABRA1 (0.52) | GABRA1TSHRGABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163926-B2 | Process for the synthesis of piperidinyl sulphonate esters | ASTRAZENECA AB (SE) | 2012-04-24 | — | — | US | disclosed |
| US-20120095229-A1 | CHEMICAL PROCESS | GENZYME CORPORATION | 2012-04-19 | — | — | US | disclosed |
| US-20090203905-A1 | CHEMICAL PROCESS | GENZYME CORPORATION | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203905-A1 | CHEMICAL PROCESS | CYP3A4, CYP3A5, CYP3A7 | GABRA1 1672/4885TSHR 3902/4885GABRG2 2583/4885 |
| US-20120095229-A1 | CHEMICAL PROCESS | CYP3A4, CYP3A5, CYP3A7 | GABRA1 1672/4885TSHR 3902/4885GABRG2 2583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.