Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | CHIT1 | Q13231 | 2/20 | 0.35 |
| ▸ | CHIA | Q9BZP6 | 2/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31278318 | 0.84 | PRKACA (0.46) | ALDH1A1NPSR1HSD17B10GAAMAPT | |
| SCHEMBL23630311 | 0.82 | ALDH1A1 (0.43) | ALDH1A1NPSR1HSD17B10GRM2GAA | |
| SCHEMBL23635325 | 0.81 | HTR3A (0.40) | GAAMAPTHTR3ACHIT1CHIA | |
| SCHEMBL23630313 | 0.80 | PRKACA (0.57) | ALDH1A1NPSR1L3MBTL1HSD17B10GRM2 | |
| SCHEMBL29711491 | 0.79 | PRKACA (0.34) | ALDH1A1NPSR1GAAMAPTPRKACA | |
| SCHEMBL21877759 | 0.73 | PRKACA (0.38) | ALDH1A1HSD17B10GAAPRKACAPRKACG | |
| SCHEMBL21877758 | 0.73 | PRKACA (0.38) | ALDH1A1HSD17B10GAAPRKACAPRKACG | |
| SCHEMBL15020704 | 0.71 | IKBKB (0.45) | NPSR1GAAMAPTLMNAMAPK1 | |
| SCHEMBL17447898 | 0.70 | PIK3CD (0.45) | ALDH1A1NPSR1HSD17B10MAPTPRKACA | |
| SCHEMBL17447896 | 0.70 | PIK3CD (0.45) | ALDH1A1NPSR1HSD17B10MAPTPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11192893-B2 | Pyrazoloquinazolinone antitumor agents | THE ROCKEFELLER UNIVERSITY (US) | 2021-12-07 | — | — | US | disclosed |
| WO-2021142420-A1 | PYRAZOLO[1,5-a]PYRIMIDIN-7(4H)-ONE INHIBITORS OF DYNEIN | KAPOOR TARUN M (US) | 2021-07-15 | — | — | WO | disclosed |
| US-20200148687-A1 | PYRAZOLOQUINAZOLINONE ANTITUMOR AGENTS | THE ROCKEFELLER UNIVERSITY (US) | 2020-05-14 | — | — | US | disclosed |
| EP-3624805-A1 | PYRAZOLOQUINAZOLINONE ANTITUMOR AGENTS | Kapoor, Tarun, M. (US) | 2020-03-25 | — | — | EP | disclosed |
| WO-2018213712-A1 | PYRAZOLOQUINAZOLINONE ANTITUMOR AGENTS | KAPOOR TARUN M (US) | 2018-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200148687-A1 | PYRAZOLOQUINAZOLINONE ANTITUMOR AGENTS | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCCS, TPD52L2 | ALDH1A1 317/4885NPSR1 3150/4885L3MBTL1 661/4885 |
| US-11192893-B2 | Pyrazoloquinazolinone antitumor agents | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCCS, TPD52L2 | ALDH1A1 317/4885NPSR1 3150/4885L3MBTL1 661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.