Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.48 |
| ▸ | RARA | P10276 | 4/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.47 |
| ▸ | MDH1 | P40925 | 1/20 | 0.47 |
| ▸ | MDH2 | P40926 | 1/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.47 |
| ▸ | RARG | P13631 | 8/20 | 0.46 |
| ▸ | RARB | P10826 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.45 |
| ▸ | GOT1 | P17174 | 1/20 | 0.45 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25230655 | 0.86 | IKBKB (0.61) | IKBKBRARAHIF1AEPAS1MDH1 | |
| SCHEMBL30428692 | 0.86 | IKBKB (0.61) | IKBKBRARAHIF1AEPAS1MDH1 | |
| SCHEMBL20565088 | 0.82 | IKBKB (0.47) | IKBKBRARAHIF1AEPAS1MDH1 | |
| SCHEMBL7927677 | 0.80 | IKBKB (0.53) | IKBKBRARAHIF1AEPAS1MDH1 | |
| SCHEMBL19639432 | 0.80 | RARA (0.67) | IKBKBRARAHIF1AEPAS1MDH1 | |
| SCHEMBL8766811 | 0.78 | RARB (0.57) | IKBKBRARAHIF1AEPAS1MDH1 | |
| SCHEMBL3315794 | 0.78 | RARB (0.56) | RARAHIF1AEPAS1MDH1MDH2 | |
| SCHEMBL27979397 | 0.76 | RARB (0.55) | RARARARGRARBMEN1NR1I2 | |
| SCHEMBL7932786 | 0.76 | IKBKB (0.55) | IKBKBRARAHIF1ARARGRARB | |
| SCHEMBL9300824 | 0.76 | RARB (0.71) | IKBKBRARAHIF1AEPAS1RARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12195424-B2 | Antibiotic compounds | THE GENERAL HOSPITAL CORPORATION (US) | 2025-01-14 | — | — | US | disclosed |
| US-20220095614-A1 | Antibiotic Compounds | THE GENERAL HOSPITAL CORPORATION | 2022-03-31 | — | — | US | disclosed |
| US-11278025-B2 | Antibiotic compounds | THE GENERAL HOSPITAL CORPORATION (US) | 2022-03-22 | — | — | US | disclosed |
| US-20200190009-A1 | Antibiotic Compounds | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2020-06-18 | — | — | US | disclosed |
| WO-2018213609-A1 | ANTIBIOTIC COMPOUNDS | AUSUBEL FREDERICK M (US) | 2018-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200190009-A1 | Antibiotic Compounds | CUTA, NRDC, CLPP | IKBKB 2203/4885RARA 30/4885HIF1A 2511/4885 |
| US-20220095614-A1 | Antibiotic Compounds | CUTA, NRDC, CLPP | IKBKB 2203/4885RARA 30/4885HIF1A 2511/4885 |
| US-12195424-B2 | Antibiotic compounds | CUTA, NRDC, CLPP | IKBKB 2203/4885RARA 30/4885HIF1A 2511/4885 |
| US-11278025-B2 | Antibiotic compounds | CUTA, NRDC, CLPP | IKBKB 2203/4885RARA 30/4885HIF1A 2511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.