Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TERT | O14746 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28941770 | 0.83 | CES1 (0.54) | ALDH1A1CES1MEN1KMT2AMAPT | |
| SCHEMBL7166308 | 0.82 | ALDH1A1 (0.50) | ALDH1A1CES1MEN1KMT2AMAPT | |
| SCHEMBL21445736 | 0.82 | TDP1 (0.55) | ALDH1A1CES1MEN1KMT2AMAPT | |
| SCHEMBL1532181 | 0.82 | TSHR (0.59) | ALDH1A1CES1MEN1KMT2AMAPT | |
| SCHEMBL27450016 | 0.80 | MAPK1 (0.57) | ALDH1A1CES1MEN1KMT2AMAPT | |
| SCHEMBL11685637 | 0.78 | HSP90AA1 (0.62) | ALDH1A1CES1MEN1KMT2AMAPT | |
| SCHEMBL11326501 | 0.76 | MAPT (0.49) | ALDH1A1CES1MEN1KMT2AMAPT | |
| SCHEMBL11339267 | 0.76 | GAA (0.56) | ALDH1A1CES1MEN1KMT2AMAPT | |
| SCHEMBL4601126 | 0.76 | TGM2 (0.51) | ALDH1A1CES1MEN1KMT2AMAPT | |
| SCHEMBL7224442 | 0.76 | ALDH1A1 (0.52) | ALDH1A1CES1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898632-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | Janssen Pharmaceutica NV (BE) | 2021-10-27 | — | — | EP | disclosed |
| WO-2020125730-A1 | HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS | JANSSEN PHARMACEUTICA NV (BE) | 2020-06-25 | — | — | WO | disclosed |
| US-10233174-B2 | Thiocarbamate prodrugs of tofacitinib | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2019-03-19 | — | — | US | disclosed |
| US-20180339980-A1 | THIOCARBAMATE PRODRUGS OF TOFACITINIB | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2018-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10233174-B2 | Thiocarbamate prodrugs of tofacitinib | JAK1, JAK3, JAK2 | ALDH1A1 2392/4885CES1 714/4885MEN1 2977/4885 |
| US-20180339980-A1 | THIOCARBAMATE PRODRUGS OF TOFACITINIB | JAK1, JAK3, JAK2 | ALDH1A1 2392/4885CES1 714/4885MEN1 2977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.