Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 10/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.51 |
| ▸ | PI4KA | P42356 | 9/20 | 0.47 |
| ▸ | PI4K2B | Q8TCG2 | 9/20 | 0.47 |
| ▸ | PI4K2A | Q9BTU6 | 9/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 9/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | AHCY | P23526 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11908593 | 0.72 | ADORA2A (0.60) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL580610 | 0.71 | ADORA2A (0.64) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL28413958 | 0.70 | ADORA2A (0.62) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL667204 | 0.70 | ADORA2A (0.62) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL5576830 | 0.69 | ADORA2A (0.56) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL21128139 | 0.69 | ADORA2A (0.56) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL5663802 | 0.69 | ADORA2A (0.51) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL1370892 | 0.68 | ADORA2A (0.60) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL13007709 | 0.68 | ADORA2A (0.60) | ADORA2AADORA1PI4KAPI4K2BPI4K2A | |
| SCHEMBL106573 | 0.68 | ADORA2A (1.00) | ADORA2AADORA1PI4KAPI4K2BPI4K2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200101048-A1 | ANTIBACTERIAL AGENTS INCLUDING HISTIDINE KINASE INHIBITORS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2020-04-02 | — | — | US | claimed |
| WO-2018217884-A1 | ANTIBACTERIAL AGENTS INCLUDING HISTIDINE KINASE INHIBITORS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2018-11-29 | — | — | WO | claimed |
| US-11452714-B2 | Antibacterial agents including histidine kinase inhibitors | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2022-09-27 | — | — | US | disclosed |
| US-11452714-B2 | Antibacterial agents including histidine kinase inhibitors | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2022-09-27 | — | — | US | disclosed |
| US-20200101048-A1 | ANTIBACTERIAL AGENTS INCLUDING HISTIDINE KINASE INHIBITORS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2020-04-02 | — | — | US | disclosed |
| US-20200101048-A1 | ANTIBACTERIAL AGENTS INCLUDING HISTIDINE KINASE INHIBITORS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2020-04-02 | — | — | US | disclosed |
| WO-2018217884-A1 | ANTIBACTERIAL AGENTS INCLUDING HISTIDINE KINASE INHIBITORS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2018-11-29 | — | — | WO | disclosed |
| WO-2018217884-A1 | ANTIBACTERIAL AGENTS INCLUDING HISTIDINE KINASE INHIBITORS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2018-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200101048-A1 | ANTIBACTERIAL AGENTS INCLUDING HISTIDINE KINASE INHIBITORS | PDXK, BLK, DCK | ADORA2A 2027/4885ADORA1 1625/4885PI4KA 458/4885 |
| US-11452714-B2 | Antibacterial agents including histidine kinase inhibitors | PDXK, BLK, DCK | ADORA2A 2027/4885ADORA1 1625/4885PI4KA 458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.