Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.35 |
| ▸ | ERN1 | O75460 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21358663 | 0.92 | LMNA (0.41) | LMNAPRKDCALDH1A3ERN1ALDH1A1 | |
| SCHEMBL20140233 | 0.86 | LMNA (0.42) | LMNAPRKDCALDH1A3ERN1ALDH1A1 | |
| SCHEMBL1315516 | 0.83 | ERN1 (0.36) | LMNAPRKDCERN1 | |
| SCHEMBL903950 | 0.79 | GABRA1 (0.37) | GABRA1GABRB2 | |
| SCHEMBL14036628 | 0.78 | ALDH1A1 (0.34) | LMNAERN1ALDH1A1POLBMAPT | |
| SCHEMBL933374 | 0.77 | ERN1 (0.43) | LMNAPRKDCERN1 | |
| SCHEMBL29655114 | 0.77 | ERN1 (0.43) | LMNAPRKDCERN1 | |
| SCHEMBL12961324 | 0.77 | MCL1 (0.34) | LMNAERN1ALDH1A1L3MBTL1 | |
| SCHEMBL1517367 | 0.76 | PRKDC (0.38) | LMNAPRKDCERN1ALDH1A1 | |
| SCHEMBL31088903 | 0.76 | PRKDC (0.38) | LMNAPRKDCERN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11649224-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2023-05-16 | — | — | US | disclosed |
| US-11649224-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2023-05-16 | — | — | US | disclosed |
| US-11649224-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2023-05-16 | — | — | US | disclosed |
| EP-3630748-B1 | IRE1 SMALL MOLECULE INHIBITORS | UNIV CORNELL (US) | 2023-04-19 | — | — | EP | disclosed |
| US-20210284628-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2021-09-16 | — | — | US | disclosed |
| US-11021466-B2 | IRE1 small molecule inhibitors | CORNELL UNIVERSITY (US) | 2021-06-01 | — | — | US | disclosed |
| US-20200157079-A1 | IRE1 Small Molecule Inhibitors | QUENTIS THERAPEUTICS, INC. (US) | 2020-05-21 | — | — | US | disclosed |
| EP-3630748-A1 | IRE1 SMALL MOLECULE INHIBITORS | Quentis Therapeutics, Inc. (US) | 2020-04-08 | — | — | EP | disclosed |
| US-20180346446-A1 | IRE1 SMALL MOLECULE INHIBITORS | CORNELL UNIVERSITY | 2018-12-06 | — | — | US | disclosed |
| WO-2018222918-A1 | IRE1 SMALL MOLECULE INHIBITORS | QUENTIS THERAPEUTICS, INC. (US) | 2018-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157079-A1 | IRE1 Small Molecule Inhibitors | XBP1, ERN2, ERN1 | LMNA 2127/4885PRKDC 818/4885ALDH1A3 3909/4885 |
| US-11021466-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | LMNA 2127/4885PRKDC 818/4885ALDH1A3 3909/4885 |
| US-20210284628-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | LMNA 2127/4885PRKDC 818/4885ALDH1A3 3909/4885 |
| US-11649224-B2 | IRE1 small molecule inhibitors | XBP1, ERN2, ERN1 | LMNA 2127/4885PRKDC 818/4885ALDH1A3 3909/4885 |
| US-20180346446-A1 | IRE1 SMALL MOLECULE INHIBITORS | XBP1, ERN2, ERN1 | LMNA 2127/4885PRKDC 818/4885ALDH1A3 3909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.