Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.40 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15474793 | 0.81 | LMNA (0.47) | MAOBHPGDTHRATHRBALOX5 | |
| SCHEMBL2093026 | 0.81 | ALOX5 (0.53) | MAOBGAAMAPTRAB9AALOX5 | |
| SCHEMBL4315473 | 0.79 | SLC6A4 (0.40) | MAOBTHRATHRBSLC6A4ALOX5 | |
| SCHEMBL10743886 | 0.79 | MAOB (0.40) | MAOBALOX5LMNACYP1A2PTGS1 | |
| SCHEMBL7295428 | 0.79 | L3MBTL1 (0.44) | MAOBGAAMAPTHPGDALOX5 | |
| SCHEMBL28006547 | 0.79 | CALM1 (0.41) | MAOBGAAMAPTHPGDRAB9A | |
| SCHEMBL7468357 | 0.79 | AGXT (0.43) | MAOBGABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL28085689 | 0.78 | MAOB (0.49) | MAOBGAAMAPTRAB9AALOX5 | |
| SCHEMBL2202368 | 0.77 | MAOB (0.58) | MAOB | |
| SCHEMBL3320555 | 0.77 | MAOB (0.56) | MAOBTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118302417-A | NLRP3 inhibitors | PTC医疗公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-110950860-B | Fused tricyclic compound and application thereof in medicines | 广东东阳光药业有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-110066278-B | Fused tricyclic compound and application thereof in medicines | 广东东阳光药业有限公司 | 2021-06-08 | — | — | CN | disclosed |
| EP-3694856-A1 | FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | Sunshine Lake Pharma Co., Ltd. (CN) | 2020-08-19 | — | — | EP | disclosed |
| CN-110950860-A | Fused tricyclic compound and application thereof in medicines | 广东东阳光药业有限公司 | 2020-04-03 | — | — | CN | disclosed |
| WO-2019100735-A1 | FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2019-05-31 | — | — | WO | disclosed |
| CN-109704982-A | A kind of preparation method of eltrombopag olamine intermediate 2- hydroxyl -3- (carboxyl phenyl) aniline | 上海天慈国际药业有限公司 | 2019-05-03 | — | — | CN | disclosed |
| WO-2018219356-A1 | FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2018-12-06 | — | — | WO | disclosed |