SCHEMBL20580

SCHEMBL20580

O=c1[nH]c(NCl)nc2nc[nH]c12

nearest known ligand 0.63

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GDA Q9Y2T3 1/20 0.63
XDH P47989 2/20 0.58
POLA1 P09884 1/20 0.58
PNP P00491 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29407603 0.83 GDA (0.63) GDAXDHPOLA1PNP
SCHEMBL2051369 0.83 GDA (0.63) GDAXDHPOLA1PNP
SCHEMBL22885 0.83 GDA (0.68) GDAXDHPOLA1PNP
SCHEMBL2983854 0.83 GDA (0.68) GDAXDHPOLA1PNP
SCHEMBL8886042 0.83 GDA (0.63) GDAXDHPOLA1PNP
SCHEMBL852109 0.83 GDA (0.63) GDAXDHPOLA1PNP
SCHEMBL41789 0.83 GDA (0.63) GDAXDHPOLA1PNP
SCHEMBL1843779 0.83 GDA (0.63) GDAXDHPOLA1PNP
SCHEMBL9960821 0.81 XDH (0.69) GDAXDHPOLA1PNP
SCHEMBL5935074 0.81 XDH (0.78) GDAXDHPOLA1PNP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630867-B2 Devices for CRISPR effector system based diagnostics THE BROAD INSTITUTE, INC. (US) 2026-05-19 US disclosed
US-20250243471-A1 PROGRAMMABLE PATTERN RECOGNITION COMPOSITIONS BROAD INST INC (US) 2025-07-31 US disclosed
US-20250223580-A1 PROGRAMMABLE NUCLEASE-PEPTIDASE COMPOSITIONS THE BROAD INSTITUTE, INC. 2025-07-10 US disclosed
US-20250129355-A1 PROGRAMMABLE NUCLEASE-PEPTIDASE COMPOSITIONS NATIONAL INSTITUTES OF HEALTH 2025-04-24 US disclosed
US-20250075268-A1 CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2025-03-06 US disclosed
US-12203145-B2 CRISPR effector system based diagnostics for virus detection THE BROAD INSTITUTE, INC. (US) 2025-01-21 US disclosed
EP-4119663-B1 CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS BROAD INST INC (US) 2024-11-27 EP disclosed
CN-111448311-B Diagnostic system based on multiple effector CRISPR 博德研究所 2024-11-19 CN disclosed
CN-111108220-B Diagnostic based on CRISPR effect system for virus detection 博德研究所 2024-11-19 CN disclosed
US-20240352454-A1 MULTI-EFFECTOR CRISPR BASED DIAGNOSTIC SYSTEMS MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2024-10-24 US disclosed
EP-1546164-A1 (+)-TRANS-ISOMERS OF (1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL) METHYL NUCLEOSIDE DERIVATIVES, PROCESS FOR THE PREPARATION OF STEREOISOMERS THEREOF, AND USE OF ANTIVIRAL AGENTS THEREOF LG Life Sciences Ltd. (KR) 2005-06-29 EP disclosed
US-20040127454-A1 Use of 5-substituted nucleosides and/or prodrugs thereof in the resistance-free treatment of infectious diseases RESPROTECT GMBH (DE) 2004-07-01 US disclosed
WO-2004029064-A1 (+)-TRANS-ISOMERS OF (1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL) METHYL NUCLEOSIDE DERIVATIVES, PROCESS FOR THE PREPARATION OF STEREOISOMERS THEREOF, AND USE OF ANTIVIRAL AGENTS THEREOF LG LIFE SCIENCES LTD. (KR) 2004-04-08 WO disclosed
EP-1334109-A2 IMPROVED SYNTHESIS OF PURINE LOCKED NUCLEIC ACID ANALOGUES Santaris Pharma A/S (DK) 2003-08-13 EP disclosed
US-20020086998-A1 Synthesis of purine locked nucleic acid analogues SANTARIS PHARMA A/S (DK) 2002-07-04 US disclosed
WO-2002028875-A2 IMPROVED SYNTHESIS OF PURINE LOCKED NUCLEIC ACID ANALOGUES CUREON A/S (DK) 2002-04-11 WO disclosed
WO-2002024323-A2 HIGH DENSITY MOLECULAR ARRAYS ON POROUS SURFACES PICOLITER INC. (US) 2002-03-28 WO disclosed
EP-0824536-B1 ANTIMALARIAL ORGANOMETALLIC IRON COMPLEXES UNIV LILLE SCIENCES TECH (FR) 2001-08-22 EP disclosed
EP-0338168-A1 Phosphonoalkylpurine derivatives MERRELL DOW PHARMACEUTICALS INC. (US) 1989-10-25 EP disclosed
US-4508898-A Antiviral triazine compounds SYNTEX (U.S.A.) INC. 1985-04-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020086998-A1 Synthesis of purine locked nucleic acid analogues RNGTT, PNP, UNG GDA 77/4885XDH 598/4885POLA1 757/4885
US-20040127454-A1 Use of 5-substituted nucleosides and/or prodrugs thereof in the resistance-free treatment of infectious diseases PNP, TYMP, ENTPD5 GDA 17/4885XDH 219/4885POLA1 684/4885
US-12630867-B2 Devices for CRISPR effector system based diagnostics ZFR, MTREX, ADAR GDA 1128/4885XDH 2266/4885POLA1 885/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.