Phorbol

Phorbol

SCHEMBL20582541

CC1=C[C@H]2[C@]3(O)[C@H](C)[C@@H](O)[C@@]4(O)[C@H]([C@@H]3C=C(CO)C[C@@]2(O)C1=O)C4(C)C.CCCCCCCCCCCCCC(=O)OC(C)=O

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 5/20 0.69
PRKCG P05129 5/20 0.69
PRKD3 O94806 4/20 0.69
PRKCB P05771 4/20 0.69
PRKCH P24723 4/20 0.69
PRKCI P41743 4/20 0.69
PRKCE Q02156 4/20 0.69
PRKCQ Q04759 4/20 0.69
PRKCZ Q05513 4/20 0.69
PRKCD Q05655 4/20 0.69
PRKD1 Q15139 4/20 0.69
USP2 O75604 2/20 0.69
TP53 P04637 2/20 0.69
KDM4E B2RXH2 1/20 0.69
ALDH1A1 P00352 1/20 0.69
SMN1; SMN2 Q16637 1/20 0.69
CYP3A4 P08684 1/20 0.69
CYP2C9 P11712 1/20 0.69
TSHR P16473 1/20 0.69
NFKB1 P19838 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phorbol SCHEMBL10620832 1.00 PRKCA (0.69) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL417521 1.00 PRKCA (0.69) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27616694 1.00 PRKCA (0.69) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL1893791 1.00 PRKCA (0.69) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27579226 0.96 PRKCA (0.67) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL21462215 0.92 PRKCA (0.66) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL5904049 0.92 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27299282 0.90 PRKCA (0.63) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL7615331 0.90 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL64353 0.90 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115210567-A Methods of assessing efficacy of MALT1 inhibitors using NF-KB translocation assays 詹森药业有限公司 2022-10-18 CN claimed
US-20200187851-A1 PERIODONTAL DISEASE STRATIFICATION AND USES THEREOF THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL 2020-06-18 US claimed
CN-103013922-B Method for eliminating alpha-synuclein generated in Parkinson's model cells by using cadmium telluride quantum dots and application thereof SHANGHAI INST APPLIED PHYSICS 2013-12-18 CN claimed
CN-103013922-A Method for eliminating alpha-synuclein generated in Parkinson's model cells by using cadmium telluride quantum dots and application thereof SHANGHAI INST APPLIED PHYSICS 2013-04-03 CN claimed
CN-1071333-A CALCIUM RECEPTOR ACTIVE MOLECULES NPS PHARMA INC (US) 1993-04-28 CN claimed
CN-122094700-A Chimeric receptors 2026-05-26 CN disclosed
CN-116322729-B Polysaccharide-enriched extract of Conus ellipticus 科学发展实验室 2026-05-12 CN disclosed
CN-120078759-A Use of suramin and derivatives and pharmaceutical compositions thereof 重庆医科大学 2025-06-03 CN disclosed
CN-119908983-A Application of gardenia pistil tissue in activation energy, protection, repair and aging resistance 嘉药学校财团法人嘉南药理大学 2025-05-02 CN disclosed
CN-119837789-A Application of gardenia in moisturizing, anti-inflammation, brightening, anti-wrinkle and anti-aging 嘉药学校财团法人嘉南药理大学 2025-04-18 CN disclosed
CN-119730876-A Genetically engineered placental mucosa-associated constant T (MAIT) cells and uses thereof 普拉里生物科技有限公司 2025-03-28 CN disclosed
CN-119656337-A Tumor cell PCBP1 gene mutation regulation CD8+Use of T cells in the preparation of immunotherapeutic drugs or formulations 中山大学附属第六医院 2025-03-21 CN disclosed
CN-1372569-A Keratinocyte growth factor-2 HUMAN GENOME SCIENCES INC (US) 2002-10-02 CN disclosed
CN-1323301-A Diarylbenzopyran derivatives as cyclooxygenase-2 inhibitors PACIFIC CORP (KR) 2001-11-21 CN disclosed
CN-1292796-A METH1 and METH2 polynucleotides and polypeptides BETH ISRAEL DICKNY MEDICAL CT (US) 2001-04-25 CN disclosed
CN-1234071-A Keratinocyte grouth factor -2(KGF-2 or fibroblast growth factor-12, FGF-12) HUMAN GENOME SCIENCES INC (US) 1999-11-03 CN disclosed
CN-1201452-A 24-homo-26, 27-hexafluoro-cholecalciferol HOFFMANN LA ROCHE (CH) 1998-12-09 CN disclosed
CN-1162919-A Combination preparation, containing cyclosporin a or FK506 or rapamycin and a xanthine derivative HOECHST AG (DE) 1997-10-22 CN disclosed
CN-1157818-A 1 alpha, 26-dihydroxy-D-homo-vitamin D3 HOFFMANN LA ROCHE (CH) 1997-08-27 CN disclosed
CN-1090204-A New application of interleukin-4 and/or interleukin-10 and antibody thereof SCHERING CORP (US) 1994-08-03 CN disclosed