Phorbol

Phorbol

SCHEMBL27616694

CC1=C[C@H]2[C@]3(O)[C@H](C)[C@@H](O)[C@@]4(O)[C@H]([C@@H]3C=C(CO)C[C@@]2(O)C1=O)C4(C)C.CCCCCCCCCC(=O)OC(C)=O

nearest known ligand 0.75

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCA P17252 5/20 0.69
PRKCG P05129 5/20 0.69
PRKD3 O94806 4/20 0.69
PRKCB P05771 4/20 0.69
PRKCH P24723 4/20 0.69
PRKCI P41743 4/20 0.69
PRKCE Q02156 4/20 0.69
PRKCQ Q04759 4/20 0.69
PRKCZ Q05513 4/20 0.69
PRKCD Q05655 4/20 0.69
PRKD1 Q15139 4/20 0.69
USP2 O75604 2/20 0.69
TP53 P04637 2/20 0.69
KDM4E B2RXH2 1/20 0.69
ALDH1A1 P00352 1/20 0.69
SMN1; SMN2 Q16637 1/20 0.69
CYP3A4 P08684 1/20 0.69
CYP2C9 P11712 1/20 0.69
TSHR P16473 1/20 0.69
NFKB1 P19838 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phorbol SCHEMBL20582541 1.00 PRKCA (0.69) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL10620832 1.00 PRKCA (0.69) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL417521 1.00 PRKCA (0.69) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL1893791 1.00 PRKCA (0.69) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27579226 0.96 PRKCA (0.67) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL21462215 0.92 PRKCA (0.66) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL5904049 0.92 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27299282 0.90 PRKCA (0.63) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL7615331 0.90 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL64353 0.90 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102137874-A Recombinant antibody composition against epidermal growth factor receptor SYMPHOGEN AS 2011-07-27 CN disclosed
CN-101675075-A Recombinant anti-epidermal growth factor receptor antibody compositions SYMPHOGEN AS 2010-03-17 CN disclosed
CN-100486985-C 9a-azalides with anti-inflammatory activity ZAMBON SPA (IT) 2009-05-13 CN disclosed
CN-1708507-A 9 a-azalides with anti-inflammatory activity ZAMBON SPA (IT) 2005-12-14 CN disclosed