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Phorbol

Phorbol

SCHEMBL7615331

CC1=C[C@H]2[C@@]3(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]([C@@H]3C=C(CO)C[C@]2(O)C1=O)C4(C)C.CC1=C[C@H]2[C@@]3(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]([C@@H]3C=C(CO)C[C@]2(O)C1=O)C4(C)C.CC1=C[C@H]2[C@@]3(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]([C@@H]3C=C(CO)C[C@]2(O)C1=O)C4(C)C.CC1=C[C@H]2[C@@]3(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]([C@@H]3C=C(CO)C[C@]2(O)C1=O)C4(C)C.CC1=C[C@H]2[C@@]3(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]([C@@H]3C=C(CO)C[C@]2(O)C1=O)C4(C)C.CC1=C[C@H]2[C@@]3(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]([C@@H]3C=C(CO)C[C@]2(O)C1=O)C4(C)C.CC1=C[C@H]2[C@@]3(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]([C@@H]3C=C(CO)C[C@]2(O)C1=O)C4(C)C.CC1=C[C@H]2[C@@]3(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]([C@@H]3C=C(CO)C[C@]2(O)C1=O)C4(C)C.CC1=C[C@H]2[C@@]3(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]([C@@H]3C=C(CO)C[C@]2(O)C1=O)C4(C)C.CC1=C[C@H]2[C@@]3(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]([C@@H]3C=C(CO)C[C@]2(O)C1=O)C4(C)C.CC1=C[C@H]2[C@@]3(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]([C@@H]3C=C(CO)C[C@]2(O)C1=O)C4(C)C.CC1=C[C@H]2[C@@]3(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]([C@@H]3C=C(CO)C[C@]2(O)C1=O)C4(C)C.CCCCCCCCCCCCCC(=O)O.CCCCCCCCCCCCCC(=O)O.CCCCCCCCCCCCCC(=O)O.CCCCCCCCCCCCCC(=O)O.CCCCCCCCCCCCCC(=O)O.CCCCCCCCCCCCCC(=O)O.CCCCCCCCCCCCCC(=O)O.CCCCCCCCCCCCCC(=O)O.CCCCCCCCCCCCCC(=O)O.CCCCCCCCCCCCCC(=O)O.CCCCCCCCCCCCCC(=O)O.CCCCCCCCCCCCCC(=O)O.CCCCCCCCCCCCCC(=O)O

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PRKCA P17252 5/20 0.62
▸ PRKCG P05129 5/20 0.62
▸ PRKD3 O94806 4/20 0.62
▸ PRKCB P05771 4/20 0.62
▸ PRKCH P24723 4/20 0.62
▸ PRKCI P41743 4/20 0.62
▸ PRKCE Q02156 4/20 0.62
▸ PRKCQ Q04759 4/20 0.62
▸ PRKCZ Q05513 4/20 0.62
▸ PRKCD Q05655 4/20 0.62
▸ PRKD1 Q15139 4/20 0.62
▸ USP2 O75604 2/20 0.62
▸ TP53 P04637 2/20 0.62
▸ KDM4E B2RXH2 1/20 0.62
▸ ALDH1A1 P00352 1/20 0.62
▸ SMN1; SMN2 Q16637 1/20 0.62
▸ CYP3A4 P08684 1/20 0.62
▸ CYP2C9 P11712 1/20 0.62
▸ TSHR P16473 1/20 0.62
▸ NFKB1 P19838 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phorbol SCHEMBL28866474 1.00 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27419386 1.00 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL64353 1.00 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL22973790 1.00 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27299282 0.98 PRKCA (0.63) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27478115 0.94 PRKCA (0.60) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL28465138 0.94 PRKCA (0.56) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27450792 0.93 PRKCA (0.62) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL23610504 0.92 PRKCA (0.61) PRKCAPRKCGPRKD3PRKCBPRKCH
Phorbol SCHEMBL27579226 0.92 PRKCA (0.67) PRKCAPRKCGPRKD3PRKCBPRKCH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1244772-A2 PATHOLOGICALLY MODIFIED MYOCARDIAL CELL, PRODUCTION AND USE THEREOF MediGene Aktiengesellschaft (DE) 2002-10-02 — — EP disclosed
WO-2001046388-A2 PATHOLOGICALLY MODIFIED MYOCARDIAL CELL, PRODUCTION AND USE THEREOF MEDIGENE AKTIENGESELLSCHAFT (DE) 2001-06-28 — — WO disclosed