Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30338404 | 0.72 | MAPT (0.39) | KIF11ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL20588191 | 0.72 | KIF11 (0.43) | KIF11MAOBALDH1A1KDM4ETDP1 | |
| SCHEMBL2815949 | 0.72 | MAPT (0.47) | KIF11ALDH1A1MEN1KMT2ACYP19A1 | |
| SCHEMBL20589001 | 0.69 | KIF11 (0.45) | KIF11MAOBALDH1A1KDM4ETDP1 | |
| SCHEMBL994398 | 0.68 | MAPT (0.43) | KIF11MAOBALDH1A1TDP1MEN1 | |
| SCHEMBL10689490 | 0.68 | KIF11 (0.39) | KIF11MAOBALDH1A1KDM4ETDP1 | |
| SCHEMBL445852 | 0.65 | KIF11 (0.54) | KIF11MAOBALDH1A1KDM4ETDP1 | |
| SCHEMBL297801 | 0.65 | KIF11 (0.54) | KIF11MAOBALDH1A1KDM4ETDP1 | |
| SCHEMBL2200527 | 0.65 | KIF11 (0.54) | KIF11MAOBALDH1A1KDM4ETDP1 | |
| SCHEMBL203678 | 0.65 | ESR1 (0.56) | KIF11MAOBALDH1A1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210380533-A1 | 2,3-DIHYDROISOINDOLE-1-CARBOXAMIDES USEFUL AS ROR-GAMMA MODULATORS | ASTRAZENECA AB (SE) | 2021-12-09 | — | — | US | disclosed |
| US-20210380533-A1 | 2,3-DIHYDROISOINDOLE-1-CARBOXAMIDES USEFUL AS ROR-GAMMA MODULATORS | ASTRAZENECA AB (SE) | 2021-12-09 | — | — | US | disclosed |
| US-11034654-B2 | 2,3-dihydroisoindole-1-carboxamides useful as ROR-gamma modulators | ASTRAZENECA AB (SE) | 2021-06-15 | — | — | US | disclosed |
| US-11034654-B2 | 2,3-dihydroisoindole-1-carboxamides useful as ROR-gamma modulators | ASTRAZENECA AB (SE) | 2021-06-15 | — | — | US | disclosed |
| EP-3638661-A1 | 2,3-DIHYDROISOINDOLE-1-CARBOXAMIDES USEFUL AS ROR-GAMMA MODULATORS | Astrazeneca AB (SE) | 2020-04-22 | — | — | EP | disclosed |
| US-20200115338-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2020-04-16 | — | — | US | disclosed |
| WO-2018229155-A1 | 2,3-DIHYDROISOINDOLE-1-CARBOXAMIDES USEFUL AS ROR-GAMMA MODULATORS | ASTRAZENECA AB (SE) | 2018-12-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115338-A1 | NOVEL COMPOUNDS | RORC, RORB, RORA | KIF11 2594/4885MAOB 4633/4885ALDH1A1 471/4885 |
| US-11034654-B2 | 2,3-dihydroisoindole-1-carboxamides useful as ROR-gamma modulators | RORA, RORC, RORB | KIF11 3040/4885MAOB 4185/4885ALDH1A1 389/4885 |
| US-20210380533-A1 | 2,3-DIHYDROISOINDOLE-1-CARBOXAMIDES USEFUL AS ROR-GAMMA MODULATORS | RORA, RORC, RORB | KIF11 3040/4885MAOB 4185/4885ALDH1A1 389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.