Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Propylhexedrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | METAP2 | P50579 | 2/20 | 0.46 |
| ▸ | METAP1 | P53582 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CCKBR | P32239 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PPM1D | O15297 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ephedrine SCHEMBL28142813 | 0.79 | CYP2D6 (0.61) | METAP2METAP1LMNACYP1A2CYP2D6 | |
| Levopropylhexedrine SCHEMBL20780004 | 0.78 | CTSK (0.42) | CTSLCTSBCTSKMETAP2CYP1A2 | |
| Levopropylhexedrine SCHEMBL161851 | 0.78 | CTSK (0.42) | CTSLCTSBCTSKMETAP2CYP1A2 | |
| Propylhexedrine SCHEMBL28537 | 0.78 | CTSK (0.42) | CTSLCTSBCTSKMETAP2CYP1A2 | |
| Benzoic Acid SCHEMBL10944963 | 0.76 | ALDH1A1 (0.56) | KMT2AEPHX2SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL4503486 | 0.76 | MMP2 (0.50) | CTSLCTSBCTSSCTSKMETAP2 | |
| Propylhexedrine SCHEMBL28890426 | 0.76 | CTSK (0.41) | CTSLCTSBCTSKMETAP2CYP1A2 | |
| Propylhexedrine SCHEMBL4900116 | 0.76 | CTSK (0.41) | CTSLCTSBCTSKMETAP2CYP1A2 | |
| Benzoic Acid SCHEMBL4096880 | 0.76 | TSHR (0.64) | LMNACYP2D6KMT2ASMN1; SMN2ATM | |
| Cyclopentamine SCHEMBL13479599 | 0.76 | CTSK (0.40) | CTSLCTSBCTSKMETAP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11077157-B2 | Medicinal composition for treating fibrosis | OSAKA UNIVERSITY (JP) | 2021-08-03 | — | — | US | disclosed |
| EP-3417866-B1 | MEDICINAL COMPOSITION FOR TREATING FIBROSIS | UNIV OSAKA (JP) | 2020-12-23 | — | — | EP | disclosed |
| US-20190151384-A1 | Medicinal Composition for Treating Fibrosis | OSAKA UNIVERSITY (JP) | 2019-05-23 | — | — | US | disclosed |
| CN-109152804-A | Pharmaceutical composition for treating fibrosis | 国立大学法人大阪大学 | 2019-01-04 | — | — | CN | disclosed |
| EP-3417866-A1 | MEDICINAL COMPOSITION FOR TREATING FIBROSIS | Osaka University (JP) | 2018-12-26 | — | — | EP | disclosed |