Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.53 |
| ▸ | CXCR1 | P25024 | 4/20 | 0.53 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.53 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.53 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290381 | 0.89 | PPARA (0.51) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL3674499 | 0.86 | PTGS2 (0.69) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL4943395 | 0.85 | PTGS2 (0.51) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL11490449 | 0.83 | LMNA (0.50) | PTGS2LMNAMAPK1TSHRBLM | |
| SCHEMBL11439247 | 0.83 | LMNA (0.50) | PTGS2LMNAMAPK1TSHRBLM | |
| SCHEMBL9425565 | 0.83 | PTGS2 (0.56) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL2391075 | 0.81 | PTGS2 (0.54) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL10276277 | 0.81 | PTGS2 (0.54) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL1345158 | 0.81 | PTGS2 (0.64) | PTGS2PTGS1CXCR1CXCR2LMNA | |
| SCHEMBL2319534 | 0.81 | PTGS2 (0.58) | PTGS2PTGS1CXCR1CXCR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148371-B2 | Adenine compound and use thereof | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2012-04-03 | — | — | US | disclosed |
| US-7754728-B2 | Adenine compound and use thereof | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2010-07-13 | — | — | US | disclosed |