L-Fucose

L-Fucose

SCHEMBL20607674

CC(O)C(O)C(O)C(O)C=O.Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ TGM2 P21980 1/20 0.67
▸ FUT5 Q11128 1/20 0.62
▸ NT5E P21589 1/20 0.62
▸ KRAS P01116 5/20 0.62
▸ P2RY6 Q15077 2/20 0.58
▸ P2RY2 P41231 1/20 0.58
▸ P2RY4 P51582 1/20 0.58
▸ IMPDH2 P12268 4/20 0.58
▸ DCPS Q96C86 1/20 0.57
▸ ENPP1 P22413 2/20 0.57
▸ P2RY1 P47900 2/20 0.57
▸ P2RY12 Q9H244 1/20 0.57
▸ P2RX3 P56373 2/20 0.56
▸ P2RX1 P51575 1/20 0.56
▸ P2RY11 Q96G91 1/20 0.56
▸ P2RX4 Q99571 1/20 0.56
▸ IMPDH1 P20839 2/20 0.56
▸ HINT1 P49773 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
L-Fucose SCHEMBL18992533 1.00 TGM2 (0.67) TGM2FUT5NT5EKRASP2RY6
L-Fucose SCHEMBL29216038 0.97 TGM2 (0.63) TGM2FUT5NT5EKRASP2RY6
Demannose SCHEMBL2182862 0.92 TGM2 (0.66) TGM2FUT5NT5EKRASP2RY6
Glucuronic Acid SCHEMBL27957333 0.92 TGM2 (0.66) TGM2FUT5NT5EKRASP2RY6
Demannose SCHEMBL5163477 0.92 TGM2 (0.66) TGM2FUT5NT5EKRASP2RY6
Demannose SCHEMBL4290630 0.92 TGM2 (0.66) TGM2FUT5NT5EKRASP2RY6
Galactose SCHEMBL6046113 0.92 TGM2 (0.66) TGM2FUT5NT5EKRASP2RY6
Demannose SCHEMBL20746287 0.92 TGM2 (0.66) TGM2FUT5NT5EKRASP2RY6
Glucuronic Acid SCHEMBL6046180 0.92 TGM2 (0.66) TGM2FUT5NT5EKRASP2RY6
Glucuronic Acid SCHEMBL5941537 0.92 TGM2 (0.66) TGM2FUT5NT5EKRASP2RY6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118165926-A Preparation method and application of targeted stem cells 天津大学 2024-06-11 — — CN claimed
CN-114574506-A Protein O-fucosyltransferase OsPOFUT1 encoding gene and enzyme, preparation and application thereof 中国科学院大连化学物理研究所 2022-06-03 — — CN claimed
CN-114207108-A Genetically modified host cells producing glycosylated cannabinoids 奥克塔林生物制剂公司 2022-03-18 — — CN claimed
EP-4422642-B1 RUTINOSYL-4-METHYLUMBELLIFERONE FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECN CONICET (AR) 2026-02-04 — — EP disclosed
US-20250222114-A1 GLYCOCONJUGATED DRUG FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA ASOCIACIÓN CIVIL DE ESTUDIOS SUPERIORES - UNIVERSIDAD AUSTRAL (AR) 2025-07-10 — — US disclosed
EP-4422642-A1 GLYCOCONJUGATED DRUG FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA Consejo Nacional de Investigaciones Científicas Y Técnicas (CONICET) (AR) 2024-09-04 — — EP disclosed
WO-2024123084-A1 METHOD FOR PRODUCING FUCOSYLLACTOSE BY USING RECOMBINANT CORYNEBACTERIUM GLUTAMICUM TRANSFORMED TO EXPRESS BETA-GALACTOSIDASE (주)에이피테크놀로지 2024-06-13 — — WO disclosed
CN-118165926-A Preparation method and application of targeted stem cells 天津大学 2024-06-11 — — CN disclosed
CN-118028206-A Engineering bacterium for preparing L-fucose and application thereof 华熙生物科技股份有限公司 2024-05-14 — — CN disclosed
US-20240093254-A1 METHOD FOR INCREASING PRODUCTIVITY OF 2'-FUCOSYLLACTOSE THROUGH CHANGES IN CULTURE MEDIUM COMPOSITION AND CULTURING ADVANCED PROTEIN TECHNOLOGIES CORP. (KR) 2024-03-21 — — US disclosed
CN-117721089-A Enzyme composition and application thereof 珠海瑞德林生物有限公司 2024-03-19 — — CN disclosed
US-20200181665-A1 FUCOSYLTRANSFERASES AND THEIR USE IN PRODUCING FUCOSYLATED OLIGOSACCHARIDES CHR. HANSEN A/S (DK) 2020-06-11 — — US disclosed
EP-3649248-A1 FUCOSYLTRANSFERASES AND THEIR USE IN PRODUCING FUCOSYLATED OLIGOSACCHARIDES Jennewein Biotechnologie GmbH (DE) 2020-05-13 — — EP disclosed
US-20200140895-A1 Recombinant bacillus subtilis for synthesizing GDP-L-fucose and application thereof JIANGNAN UNIVERSITY (CN) 2020-05-07 — — US disclosed
CN-110869508-A Fucosyltransferases and their use in the production of fucosylated oligosaccharides 詹尼温生物技术有限责任公司 2020-03-06 — — CN disclosed
US-20190192691-A1 REGULATED BIOCIRCUIT SYSTEMS OBSIDIAN THERAPEUTICS, INC. 2019-06-27 — — US disclosed
CN-109749976-A A kind of recombined bacillus subtilis efficiently synthesizing guanosine diphosphate fucose and its construction method and application 光明乳业股份有限公司 2019-05-14 — — CN disclosed
WO-2019008133-A1 FUCOSYLTRANSFERASES AND THEIR USE IN PRODUCING FUCOSYLATED OLIGOSACCHARIDES JENNEWEIN BIOTECHNOLOGIE GMBH (DE) 2019-01-10 — — WO disclosed
EP-3425052-A1 FUCOSYLTRANSFERASES AND THEIR USE IN PRODUCING FUCOSYLATED OLIGOSACCHARIDES Jennewein Biotechnologie GmbH (DE) 2019-01-09 — — EP disclosed
CN-106795484-A For α (1,2) the fucosyltransferase mutation used when fucosylation oligosaccharide is produced 格里康辛有限责任公司 2017-05-31 — — CN disclosed
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