Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.66 |
| ▸ | HTT | P42858 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.62 |
| ▸ | RELA | Q04206 | 1/20 | 0.62 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.62 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | IDE | P14735 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29769093 | 1.00 | ALDH1A1 (0.66) | ALDH1A1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL242441 | 0.84 | GAA (0.69) | ALDH1A1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL7049102 | 0.84 | GAA (0.60) | ALDH1A1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL6221391 | 0.84 | GAA (0.69) | ALDH1A1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL30410222 | 0.83 | ALDH1A1 (0.61) | ALDH1A1HTTLMNASMN1; SMN2KMT2A | |
| SCHEMBL7800482 | 0.83 | GAA (0.72) | ALDH1A1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL29937693 | 0.83 | ALDH1A1 (0.68) | ALDH1A1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL398803 | 0.83 | ALDH1A1 (0.61) | ALDH1A1HTTLMNASMN1; SMN2KMT2A | |
| SCHEMBL2103553 | 0.83 | ALDH1A1 (0.68) | ALDH1A1HTTLMNASMN1; SMN2MAPT | |
| SCHEMBL13241732 | 0.82 | ALDH1A1 (0.63) | ALDH1A1HTTLMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6379400-B1 | DYEING FIBERS, SOLVENT OF WATER OR ALCOHOL AND NITROANILINE DYE | WELLA AKTIENGESELLSCHAFT (DE) | 2002-04-30 | — | — | US | claimed |
| EP-1037593-A1 | AGENT AND METHOD FOR DYEING FIBRES | Wella Aktiengesellschaft (DE) | 2000-09-27 | — | — | EP | claimed |
| WO-2000021496-A1 | AGENT AND METHOD FOR DYEING FIBRES | WELLA AKTIENGESELLSCHAFT (DE) | 2000-04-20 | — | — | WO | claimed |
| US-20240317758-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. | 2024-09-26 | — | — | US | disclosed |
| US-20240132480-A1 | INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASE | TRI-INSTITUTIONAL THERAPEUTICS DISCOVERY INSTITUTE, INC. | 2024-04-25 | — | — | US | disclosed |
| CN-117597346-A | NEK7 inhibitors | 哈利亚治疗公司 | 2024-02-23 | — | — | CN | disclosed |
| EP-4320127-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| CN-115215816-B | Synthesis method of lactam compound | 普济生物科技（台州）有限公司 | 2024-02-02 | — | — | CN | disclosed |
| US-20230210853-A1 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | Halia Therapeutics, Inc. | 2023-07-06 | — | — | US | disclosed |
| CN-115215816-A | Synthesis method of lactam compound | 普济生物科技（台州）有限公司 | 2022-10-21 | — | — | CN | disclosed |
| WO-2022150574-A1 | INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASE | CORNELL UNIVERSITY (US) | 2022-07-14 | — | — | WO | disclosed |
| EP-1916249-A1 | 3-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(thio)oxo-2-(thio)oxo-azolidin-5-ylidene derivatives as antibacterial agents | LEK Pharmaceuticals D.D. (SI) | 2008-04-30 | — | — | EP | disclosed |
| WO-2008043733-A1 | 3- (BENZO [D] [1,3] DIOXOL-5-YLMETHYL) -4- (THIO) OXO-2- (THIO) OXO-AZOLIDIN-5-YLIDENE DERIVATIVES AS ANTIBACTERIAL AGENTS | LEK PHARMACEUTICAL D.D. (SI) | 2008-04-17 | — | — | WO | disclosed |
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |
| CN-1950345-A | Morpholinylanilinoquinazoline derivatives for use as antiviral agents | ARROW THERAPEUTICS LTD (GB) | 2007-04-18 | — | — | CN | disclosed |
| EP-1748991-A1 | MORPHOLINYLANILINOQUINAZO- LINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS | Arrow Therapeutics Limited (GB) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005105761-A1 | MORPHOLINYLANILINOQUINAZO- LINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS | ARROW THERAPEUTICS LIMITED (GB) | 2005-11-10 | — | — | WO | disclosed |
| US-6379400-B1 | DYEING FIBERS, SOLVENT OF WATER OR ALCOHOL AND NITROANILINE DYE | WELLA AKTIENGESELLSCHAFT (DE) | 2002-04-30 | — | — | US | disclosed |
| EP-1037593-A1 | AGENT AND METHOD FOR DYEING FIBRES | Wella Aktiengesellschaft (DE) | 2000-09-27 | — | — | EP | disclosed |
| WO-2000021496-A1 | AGENT AND METHOD FOR DYEING FIBRES | WELLA AKTIENGESELLSCHAFT (DE) | 2000-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240132480-A1 | INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASE | DLD, GCDH, DLAT | ALDH1A1 188/4885HTT 3908/4885LMNA 1528/4885 |
| US-20230210853-A1 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | NEK7, NLRP3, NOD1 | ALDH1A1 4542/4885HTT 1380/4885LMNA 334/4885 |
| US-20240317758-A1 | NEK7 INHIBITORS | NEK7, NEK5, NEK1 | ALDH1A1 4225/4885HTT 3535/4885LMNA 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.