Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 7/20 | 0.34 |
| ▸ | NPC1 | O15118 | 6/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPY2R | P49146 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776285 | 0.91 | NPC1 (0.36) | HRH3RAB9ANPC1MEN1KMT2A | |
| SCHEMBL20631689 | 0.88 | GRIN1 (0.33) | RAB9ANPC1MEN1KMT2ARXFP1 | |
| SCHEMBL20631692 | 0.84 | SLC27A1 (0.36) | RAB9ANPC1MEN1KMT2ARXFP1 | |
| SCHEMBL17618763 | 0.83 | RAB9A (0.41) | HRH3RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20632380 | 0.81 | USP2 (0.36) | USP2TDP1NPY2R | |
| SCHEMBL20632784 | 0.81 | KARS1 (0.38) | RAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL16775975 | 0.81 | ALDH1A1 (0.40) | MEN1KMT2AUSP2SMN1; SMN2NPY2R | |
| SCHEMBL20633174 | 0.81 | SMN1; SMN2 (0.38) | RAB9ANPC1USP2SMN1; SMN2NR3C1 | |
| SCHEMBL16776275 | 0.80 | PIK3CG (0.36) | RAB9ANPC1MEN1KMT2ARXFP1 | |
| SCHEMBL20631665 | 0.80 | SLC9A1 (0.35) | MEN1KMT2AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |