Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28797790 | 0.93 | RORC (0.46) | RORCMRGPRX4PPARGPOLQHTT | |
| SCHEMBL29654248 | 0.93 | RORC (0.46) | RORCMRGPRX4PPARGPOLQHTT | |
| SCHEMBL21925043 | 0.89 | RORC (0.52) | RORCMRGPRX4PPARGMAPTPOLQ | |
| SCHEMBL29654030 | 0.87 | RORC (0.42) | RORCMRGPRX4MAPTPOLQHTT | |
| SCHEMBL28797832 | 0.87 | RORC (0.42) | RORCMRGPRX4MAPTPOLQHTT | |
| SCHEMBL19360544 | 0.85 | RORC (0.65) | RORCMRGPRX4PPARGPOLQKDM4E | |
| SCHEMBL29465606 | 0.85 | RORC (0.65) | RORCMRGPRX4PPARGPOLQKDM4E | |
| SCHEMBL20635394 | 0.83 | RORC (0.54) | RORCMRGPRX4POLQHTTHTR2A | |
| SCHEMBL28797802 | 0.81 | RORC (0.44) | RORCMRGPRX4PPARGMAPTPOLQ | |
| SCHEMBL19360524 | 0.81 | RORC (0.62) | RORCPPARGMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109952298-B | Indole carboxamide derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-09-03 | — | — | CN | disclosed |
| EP-3650448-A1 | INDOLE-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2020-05-13 | — | — | EP | disclosed |
| US-20200131123-A1 | INDOLE-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2020-04-30 | — | — | US | disclosed |
| WO-2019007382-A1 | INDOLE-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | 江苏恒瑞医药股份有限公司 | 2019-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200131123-A1 | INDOLE-FORMAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | TPH1, TPH2, PAH | RORC 2084/4885MRGPRX4 1945/4885PPARG 1967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.