Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | VNN1 | O95497 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20645608 | 0.92 | HPGD (0.50) | PARP1PARP2PRMT5L3MBTL3KMT2A | |
| SCHEMBL23884753 | 0.88 | ALDH1A1 (0.49) | L3MBTL3KMT2AALDH1A1GAAHPGD | |
| SCHEMBL15473451 | 0.84 | KMT2A (0.57) | PARP1PARP2PRMT5L3MBTL3KMT2A | |
| SCHEMBL12947988 | 0.84 | KMT2A (0.57) | PARP1PARP2PRMT5L3MBTL3KMT2A | |
| SCHEMBL24073009 | 0.84 | HSD11B1 (0.51) | PARP1PARP2PRMT5L3MBTL3VNN1 | |
| SCHEMBL31003284 | 0.84 | HSD11B1 (0.51) | PARP1PARP2PRMT5L3MBTL3VNN1 | |
| SCHEMBL967429 | 0.83 | L3MBTL3 (0.54) | PARP1PARP2PRMT5L3MBTL3KMT2A | |
| SCHEMBL967428 | 0.83 | L3MBTL3 (0.54) | PARP1PARP2PRMT5L3MBTL3KMT2A | |
| SCHEMBL25772130 | 0.82 | ACHE (0.59) | PARP1PARP2PRMT5L3MBTL3KMT2A | |
| SCHEMBL22622412 | 0.81 | RECQL (0.55) | L3MBTL3KMT2AALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019011217-A1 | PYRROLO[1,2-B]PYRIDAZINE COMPOUNDS OR PHARMACOLOGICALLY ACCEPTABLE SALTS THEREOF AND USE THEREOF | 中国科学院上海药物研究所 | 2019-01-17 | — | — | WO | disclosed |