SCHEMBL967429

SCHEMBL967429

COC1CCN(C(=O)c2ccc(Br)cc2)C1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
L3MBTL3 Q96JM7 2/20 0.54
L3MBTL1 Q9Y468 1/20 0.54
HPGD P15428 1/20 0.53
POLB P06746 3/20 0.51
KMT2A Q03164 1/20 0.51
PARP1 P09874 1/20 0.50
PARP2 Q9UGN5 1/20 0.50
MGLL Q99685 1/20 0.50
HSD11B1 P28845 1/20 0.50
PRMT5 O14744 1/20 0.49
EPHX2 P34913 1/20 0.47
GAA P10253 1/20 0.46
VNN1 O95497 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL967428 1.00 L3MBTL3 (0.54) L3MBTL3L3MBTL1HPGDPOLBKMT2A
SCHEMBL12947988 0.87 KMT2A (0.57) L3MBTL3HPGDPOLBKMT2APARP1
SCHEMBL31003284 0.87 HSD11B1 (0.51) L3MBTL3L3MBTL1HPGDPOLBPARP1
SCHEMBL15473451 0.87 KMT2A (0.57) L3MBTL3HPGDPOLBKMT2APARP1
SCHEMBL24073009 0.87 HSD11B1 (0.51) L3MBTL3L3MBTL1HPGDPOLBPARP1
SCHEMBL25772130 0.85 ACHE (0.59) L3MBTL3L3MBTL1HPGDKMT2APARP1
SCHEMBL1447851 0.83 L3MBTL3 (0.49) L3MBTL3L3MBTL1HPGDPOLBKMT2A
SCHEMBL4756718 0.83 L3MBTL3 (0.49) L3MBTL3L3MBTL1HPGDPOLBKMT2A
SCHEMBL20645779 0.83 PARP1 (0.48) L3MBTL3L3MBTL1HPGDPOLBKMT2A
SCHEMBL20625310 0.83 MEN1 (0.56) HPGDPOLBKMT2APARP1PARP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7871982-B2 Lincomycin derivatives and antimicrobial agents comprising the same as active ingredient MEIJI SEIKA KAISHA, LTD. (JP) 2011-01-18 US disclosed
US-20090156512-A1 potent activity against resistant pneumococci MEIJI SEIKA KAISHA, LTD. (JP) 2009-06-18 US disclosed
EP-1970377-A1 LINCOMYCIN DERIVATIVE AND ANTIBACTERIAL AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT MEIJI SEIKA KAISHA LTD. (JP) 2008-09-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090156512-A1 potent activity against resistant pneumococci H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NAT1, NPM1 L3MBTL3 93/4885L3MBTL1 17/4885HPGD 2051/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.