Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.36 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20653037 | 1.00 | ADORA3 (0.40) | ADORA3HIF1ABRAFPIK3CGTRPC4 | |
| SCHEMBL20652764 | 1.00 | ADORA3 (0.40) | ADORA3HIF1ABRAFPIK3CGTRPC4 | |
| SCHEMBL20656213 | 0.95 | TRPC4 (0.37) | ADORA3HIF1ATRPC4TRPC5KCNH2 | |
| SCHEMBL20656223 | 0.95 | TRPC4 (0.37) | ADORA3HIF1ATRPC4TRPC5KCNH2 | |
| SCHEMBL20652832 | 0.94 | PKM (0.39) | ADORA3TRPC4TRPC5KCNH2ALDH1A1 | |
| SCHEMBL20652949 | 0.94 | PKM (0.39) | ADORA3TRPC4TRPC5KCNH2ALDH1A1 | |
| SCHEMBL20652976 | 0.94 | PKM (0.39) | ADORA3TRPC4TRPC5KCNH2ALDH1A1 | |
| SCHEMBL20653072 | 0.90 | ADORA3 (0.42) | ADORA3HIF1ABRAFPIK3CGTRPC4 | |
| SCHEMBL20655924 | 0.90 | PKM (0.38) | ADORA3TRPC4TRPC5KCNH2ALDH1A1 | |
| SCHEMBL20656215 | 0.88 | P2RX3 (0.36) | ADORA3HIF1AALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10329292-B2 | Substituted xanthine derivatives | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-06-25 | — | — | US | disclosed |
| US-20190016722-A1 | NOVEL SUBSTITUTED XANTHINE DERIVATIVES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10329292-B2 | Substituted xanthine derivatives | TRPC5, TRPV1, TRPC4 | ADORA3 352/4885HIF1A 2040/4885BRAF 1913/4885 |
| US-20190016722-A1 | NOVEL SUBSTITUTED XANTHINE DERIVATIVES | TRPC5, TRPC4, TRPV1 | ADORA3 366/4885HIF1A 1965/4885BRAF 2217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.