Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | GAA | P10253 | 3/20 | 0.73 |
| ▸ | PKM | P14618 | 1/20 | 0.73 |
| ▸ | VCP | P55072 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 11/20 | 0.72 |
| ▸ | NPC1 | O15118 | 10/20 | 0.72 |
| ▸ | MEN1 | O00255 | 11/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.70 |
| ▸ | MAPT | P10636 | 6/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | CASP3 | P42574 | 2/20 | 0.68 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.68 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.68 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.68 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1822161 | 0.87 | KMT2A (0.73) | SMN1; SMN2ALDH1A1KDM4EGAAPKM | |
| SCHEMBL10697632 | 0.87 | ALDH1A1 (0.76) | SMN1; SMN2TDP1ALDH1A1KDM4EGAA | |
| SCHEMBL16607311 | 0.87 | ALDH1A1 (1.00) | SMN1; SMN2TDP1ALDH1A1KDM4EGAA | |
| SCHEMBL28707165 | 0.85 | NPC1 (0.72) | SMN1; SMN2TDP1ALDH1A1KDM4EGAA | |
| SCHEMBL29654038 | 0.85 | NPC1 (0.72) | SMN1; SMN2TDP1ALDH1A1KDM4EGAA | |
| SCHEMBL1886996 | 0.85 | VCP (1.00) | SMN1; SMN2TDP1ALDH1A1GAAPKM | |
| SCHEMBL206486 | 0.85 | MEN1 (0.76) | SMN1; SMN2TDP1ALDH1A1GAAPKM | |
| SCHEMBL205932 | 0.84 | GAA (0.65) | SMN1; SMN2TDP1ALDH1A1KDM4EGAA | |
| SCHEMBL14155921 | 0.84 | RAB9A (1.00) | SMN1; SMN2TDP1GAAPKMVCP | |
| SCHEMBL208199 | 0.84 | RAB9A (0.82) | SMN1; SMN2TDP1ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088806-B2 | Thiazole compounds and methods of use | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-01-03 | — | — | US | claimed |
| US-20120108576-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20120108576-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20120108576-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-8088806-B2 | Thiazole compounds and methods of use | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088806-B2 | Thiazole compounds and methods of use | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088806-B2 | Thiazole compounds and methods of use | ACHILLION PHARMACEUTICALS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20070004711-A1 | Thiazole compounds and methods of use | ACHILLION PHARMACEUTICALS, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20070004711-A1 | Thiazole compounds and methods of use | ACHILLION PHARMACEUTICALS, INC. | 2007-01-04 | — | — | US | disclosed |
| US-20070004711-A1 | Thiazole compounds and methods of use | ACHILLION PHARMACEUTICALS, INC. | 2007-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108576-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE | PIGS, CPT1A, SLC10A1 | SMN1; SMN2 3252/4885TDP1 1045/4885ALDH1A1 109/4885 |
| US-20070004711-A1 | Thiazole compounds and methods of use | PIGS, CPT1A, SLC10A1 | SMN1; SMN2 3252/4885TDP1 1045/4885ALDH1A1 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.