Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GID4 | Q8IVV7 | 2/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9970047 | 0.94 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2TSHRL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL3214465 | 0.86 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2TSHRL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL2067618 | 0.85 | GID4 (0.44) | GID4 | |
| Trifluoroacetic Acid SCHEMBL2067284 | 0.85 | GID4 (0.49) | GID4ALDH1A1HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL2067279 | 0.84 | GID4 (0.43) | GID4CRHR1 | |
| Trifluoroacetic Acid SCHEMBL9929835 | 0.82 | LMNA (0.46) | GID4LMNA | |
| Trifluoroacetic Acid SCHEMBL2066792 | 0.82 | GID4 (0.41) | NPC1RAB9ASMN1; SMN2GID4KDM4E | |
| Trifluoroacetic Acid SCHEMBL2066888 | 0.82 | CHRNA7 (0.41) | GID4 | |
| Trifluoroacetic Acid SCHEMBL2067418 | 0.81 | KDM4E (0.49) | TSHRKDM4EALDH1A1HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL9929832 | 0.80 | SIGMAR1 (0.49) | TSHRGID4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170860-B9 | BENZIMIDAZOLE DERIVATIVES | PFIZER (US) | 2017-02-22 | — | — | EP | disclosed |
| EP-2170860-B1 | BENZIMIDAZOLE DERIVATIVES | PFIZER (US) | 2016-11-02 | — | — | EP | disclosed |
| US-8431597-B2 | Benzimidazole derivatives | PFIZER INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-20120157495-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. | 2012-06-21 | — | — | US | disclosed |
| US-8148401-B2 | Benzimidazole derivatives | PFIZER INC. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20090005416-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005416-A1 | BENZIMIDAZOLE DERIVATIVES | BOD1L1, H1-3, BRIX1 | NPC1 2444/4885RAB9A 1426/4885SMN1; SMN2 1764/4885 |
| US-20120157495-A1 | BENZIMIDAZOLE DERIVATIVES | BOD1L1, H1-3, BRIX1 | NPC1 2444/4885RAB9A 1426/4885SMN1; SMN2 1764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.