Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.49 |
| ▸ | GID4 | Q8IVV7 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9970065 | 0.95 | SIGMAR1 (0.51) | SIGMAR1GID4PKMTSHR | |
| Trifluoroacetic Acid SCHEMBL2067284 | 0.93 | GID4 (0.49) | SIGMAR1GID4 | |
| SCHEMBL9970051 | 0.87 | GID4 (0.54) | SIGMAR1GID4 | |
| Trifluoroacetic Acid SCHEMBL9929835 | 0.86 | LMNA (0.46) | SIGMAR1GID4 | |
| Trifluoroacetic Acid SCHEMBL2067618 | 0.84 | GID4 (0.44) | GID4 | |
| Trifluoroacetic Acid SCHEMBL2067521 | 0.84 | CXCR3 (0.44) | GID4 | |
| Trifluoroacetic Acid SCHEMBL2066792 | 0.83 | GID4 (0.41) | GID4 | |
| Trifluoroacetic Acid SCHEMBL2066503 | 0.82 | GID4 (0.41) | GID4 | |
| Trifluoroacetic Acid SCHEMBL2067279 | 0.82 | GID4 (0.43) | GID4 | |
| Trifluoroacetic Acid SCHEMBL2067270 | 0.81 | HCRTR1 (0.41) | GID4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431597-B2 | Benzimidazole derivatives | PFIZER INC. (US) | 2013-04-30 | — | — | US | disclosed |
| US-20120157495-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157495-A1 | BENZIMIDAZOLE DERIVATIVES | BOD1L1, H1-3, BRIX1 | SIGMAR1 1710/4885GID4 3978/4885PKM 349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.