Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 10/20 | 0.41 |
| ▸ | MGAM | O43451 | 9/20 | 0.41 |
| ▸ | AMY1A | P0DUB6 | 9/20 | 0.41 |
| ▸ | SI | P14410 | 9/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 9/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.38 |
| ▸ | F12 | P00748 | 5/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20850940 | 0.73 | DGAT1 (0.50) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL21737729 | 0.72 | DGAT1 (0.66) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL15218673 | 0.70 | DGAT1 (0.72) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL25794833 | 0.70 | DGAT1 (0.49) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL2732640 | 0.69 | DGAT1 (1.00) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL3689328 | 0.69 | GAA (0.58) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL14362020 | 0.67 | DGAT1 (0.61) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL1520814 | 0.67 | DGAT1 (0.72) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL25944049 | 0.67 | GAA (0.42) | DGAT1GAAMGAMAMY1ASI | |
| SCHEMBL23110047 | 0.67 | DGAT1 (0.49) | DGAT1GAAMGAMAMY1ASI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237418-B1 | TRIAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF | NOVARTIS AG (CH) | 2019-01-30 | — | — | EP | disclosed |