Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 8/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 2/20 | 0.31 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | RGS12 | O14924 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22183082 | 0.90 | PDK2 (0.35) | PDK2AKR1A1AKR1B1MDM2 | |
| SCHEMBL19728550 | 0.89 | ALDH1A1 (0.34) | PDK2ALDH1A1GSK3AGSK3BMEN1 | |
| SCHEMBL22183373 | 0.89 | L3MBTL1 (0.35) | PDK2MEN1LMNAKMT2A | |
| SCHEMBL20687355 | 0.89 | PGR (0.32) | PDK2GSK3AGSK3BMEN1RGS12 | |
| SCHEMBL20232133 | 0.87 | ALDH1A1 (0.38) | ALDH1A1MEN1LMNAMAPTMAPK1 | |
| SCHEMBL29892197 | 0.87 | ALDH1A1 (0.40) | ALDH1A1MEN1LMNACYP1A2POLB | |
| SCHEMBL8783916 | 0.87 | ALDH1A1 (0.40) | ALDH1A1MEN1LMNACYP1A2POLB | |
| SCHEMBL22183243 | 0.86 | PDK2 (0.37) | PDK2AKR1A1AKR1B1 | |
| SCHEMBL18821322 | 0.85 | PDK2 (0.38) | PDK2AKR1A1AKR1B1GSK3AGSK3B | |
| SCHEMBL21303333 | 0.84 | PDK2 (0.41) | PDK2ALDH1A1GSK3BMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200212301-A1 | SPIROBIFLUORENE DERIVATIVES FOR USE IN ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2020-07-02 | — | — | US | disclosed |
| WO-2019020654-A1 | SPIROBIFLUORENE DERIVATIVES FOR USE IN ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2019-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200212301-A1 | SPIROBIFLUORENE DERIVATIVES FOR USE IN ELECTRONIC DEVICES | SELE, KCNB2, SCNN1B | PDK2 382/4885AKR1A1 1179/4885AKR1B1 894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.