Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 6/20 | 0.37 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.31 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22183082 | 0.97 | PDK2 (0.35) | PDK2AKR1A1AKR1B1EDNRADNM1 | |
| SCHEMBL21138925 | 0.91 | PDK2 (0.36) | PDK2 | |
| SCHEMBL15213618 | 0.91 | PDK2 (0.36) | PDK2 | |
| SCHEMBL22183373 | 0.91 | L3MBTL1 (0.35) | PDK2EDNRADNM1 | |
| SCHEMBL17816795 | 0.90 | PDK2 (0.35) | PDK2 | |
| SCHEMBL16810745 | 0.90 | PDK2 (0.35) | PDK2 | |
| SCHEMBL20232306 | 0.89 | PDK2 (0.35) | PDK2 | |
| SCHEMBL18457743 | 0.88 | TSPO (0.36) | PDK2DNM1 | |
| SCHEMBL16810747 | 0.86 | TSPO (0.35) | PDK2DNM1 | |
| SCHEMBL8784649 | 0.86 | TSPO (0.36) | PDK2EDNRADNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200212301-A1 | SPIROBIFLUORENE DERIVATIVES FOR USE IN ELECTRONIC DEVICES | MERCK PATENT GMBH (DE) | 2020-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200212301-A1 | SPIROBIFLUORENE DERIVATIVES FOR USE IN ELECTRONIC DEVICES | SELE, KCNB2, SCNN1B | PDK2 382/4885AKR1A1 1179/4885AKR1B1 894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.