SCHEMBL20703151

SCHEMBL20703151

CC(=O)OCC(=O)c1ccc(Cl)c(F)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.49
HPGD P15428 3/20 0.48
KDM4E B2RXH2 2/20 0.48
TP53 P04637 1/20 0.48
HSD17B10 Q99714 1/20 0.48
AGTR1 P30556 2/20 0.47
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
MAPT P10636 2/20 0.42
USP2 O75604 1/20 0.41
TSHR P16473 1/20 0.41
KCNQ3 O43525 2/20 0.40
KCNQ2 O43526 2/20 0.40
KCNE1 P15382 2/20 0.40
KCNQ1 P51787 2/20 0.40
KCNQ5 Q9NR82 1/20 0.40
NPC1 O15118 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11754844 0.85 ALDH1A1 (0.61) ALDH1A1HPGDKDM4ETP53HSD17B10
SCHEMBL5458228 0.84 SLC6A4 (0.44) ALDH1A1HPGDKDM4EAGTR1CYP1A2
SCHEMBL11754842 0.83 ALDH1A1 (0.50) ALDH1A1HPGDKDM4ETP53HSD17B10
SCHEMBL10780708 0.81 RAB9A (0.46) ALDH1A1HPGDKDM4EAGTR1CYP1A2
SCHEMBL20702769 0.81 AGTR1 (0.44) ALDH1A1HPGDKDM4EAGTR1CYP1A2
SCHEMBL7432445 0.80 MAPT (0.57) ALDH1A1HPGDKDM4ETP53HSD17B10
SCHEMBL20702727 0.79 ALDH1A1 (0.43) ALDH1A1HPGDKDM4ETP53HSD17B10
SCHEMBL18538090 0.78 MAPT (0.54) ALDH1A1HPGDCYP3A4MAPTTSHR
SCHEMBL6559766 0.78 KCNQ3 (0.47) HPGDTSHRKCNQ3KCNQ2KCNE1
SCHEMBL30467135 0.78 KCNQ3 (0.47) HPGDTSHRKCNQ3KCNQ2KCNE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12258323-B2 Dihydrooxadiazinones BAYER AKTIENGESELLSCHAFT (DE) 2025-03-25 US disclosed
CN-111212647-B Dihydro oxadiazinones 拜耳股份有限公司 2024-05-14 CN disclosed
US-11773070-B2 Dihydrooxadiazinones BAYER AKTIENGESELLSCHAFT (DE) 2023-10-03 US disclosed
US-11773070-B2 Dihydrooxadiazinones BAYER AKTIENGESELLSCHAFT (DE) 2023-10-03 US disclosed
US-11773070-B2 Dihydrooxadiazinones BAYER AKTIENGESELLSCHAFT (DE) 2023-10-03 US disclosed
EP-3661517-B1 DIHYDROOXADIAZINONES BAYER AG (DE) 2023-09-13 EP disclosed
EP-3661517-B1 DIHYDROOXADIAZINONES BAYER AG (DE) 2023-09-13 EP disclosed
US-20230017200-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2023-01-19 US disclosed
US-20230017200-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2023-01-19 US disclosed
US-20220396554-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2022-12-15 US disclosed
US-20220396554-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2022-12-15 US disclosed
US-11427553-B2 Dihydrooxadiazinones BAYER AKTIENGESELLSCHAFT (DE) 2022-08-30 US disclosed
US-20200369633-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2020-11-26 US disclosed
US-20200369633-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2020-11-26 US disclosed
EP-3661517-A1 DIHYDROOXADIAZINONES Bayer Aktiengesellschaft (DE) 2020-06-10 EP disclosed
CN-111212647-A Dihydroxadiazinones 拜耳股份有限公司 2020-05-29 CN disclosed
WO-2019025562-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2019-02-07 WO disclosed
WO-2019025562-A1 DIHYDROOXADIAZINONES BAYER AKTIENGESELLSCHAFT (DE) 2019-02-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200369633-A1 DIHYDROOXADIAZINONES CCND2, CCNT2, CCND1 ALDH1A1 333/4885HPGD 50/4885KDM4E 1797/4885
US-11773070-B2 Dihydrooxadiazinones CCND2, DPYD, DHPS ALDH1A1 272/4885HPGD 47/4885KDM4E 1740/4885
US-20220396554-A1 DIHYDROOXADIAZINONES CCND2, DPYD, DHPS ALDH1A1 272/4885HPGD 47/4885KDM4E 1740/4885
US-12258323-B2 Dihydrooxadiazinones CCND2, CCNT2, CCND1 ALDH1A1 333/4885HPGD 50/4885KDM4E 1797/4885
US-20230017200-A1 DIHYDROOXADIAZINONES CCND2, CCNT2, CCND1 ALDH1A1 333/4885HPGD 50/4885KDM4E 1797/4885
US-11427553-B2 Dihydrooxadiazinones CCND2, CCNT2, CCND1 ALDH1A1 333/4885HPGD 50/4885KDM4E 1797/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.