Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13342413 | 0.77 | FFAR4 (0.38) | SKP2NPC1HPGDMAPK1HTT | |
| SCHEMBL29295181 | 0.77 | FFAR4 (0.38) | SKP2NPC1HPGDMAPK1HTT | |
| SCHEMBL15787572 | 0.73 | MAOA (0.41) | SKP2 | |
| SCHEMBL19193338 | 0.70 | SIGMAR1 (0.44) | SIGMAR1NOS3NOS1NOS2HRH3 | |
| SCHEMBL26676087 | 0.69 | PTGS2 (0.32) | — | |
| SCHEMBL22624601 | 0.69 | SIGMAR1 (0.61) | SIGMAR1FDPS | |
| SCHEMBL20019766 | 0.69 | L3MBTL1 (0.46) | SIGMAR1NOS3NOS1NOS2 | |
| SCHEMBL22917999 | 0.69 | CYP1A2 (0.41) | SIGMAR1SKP2HRH3 | |
| SCHEMBL18553018 | 0.69 | PTGS1 (0.40) | NOS3NOS1NOS2NPC1HPGD | |
| SCHEMBL21444515 | 0.67 | HRH3 (0.48) | HRH3NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237406-B1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2019-02-06 | — | — | EP | disclosed |