Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.59 |
| ▸ | HTR6 | P50406 | 2/20 | 0.59 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.59 |
| ▸ | HTR3B | O95264 | 2/20 | 0.59 |
| ▸ | HTR3A | P46098 | 2/20 | 0.59 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.59 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6714846 | 0.87 | ALDH1A1 (0.75) | ALDH1A1LMNAMAPTALOX12SMN1; SMN2 | |
| SCHEMBL11100857 | 0.87 | ALDH1A1 (0.75) | ALDH1A1LMNAMAPTALOX12SMN1; SMN2 | |
| SCHEMBL9646111 | 0.85 | ALDH1A1 (0.73) | ALDH1A1LMNAMAPTALOX12SMN1; SMN2 | |
| SCHEMBL13801242 | 0.81 | CHRM2 (0.53) | ALDH1A1LMNAMAPTALOX12SMN1; SMN2 | |
| SCHEMBL23222244 | 0.81 | DRD2 (0.56) | ALDH1A1LMNAMAPTHTR7 | |
| SCHEMBL5698648 | 0.81 | SMN1; SMN2 (0.47) | LMNAMAPTSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL11889954 | 0.81 | ADRB1 (0.57) | ALDH1A1LMNAMAPTSMN1; SMN2HTR7 | |
| SCHEMBL4052281 | 0.81 | AKR1C3 (0.52) | ALDH1A1LMNAMAPTSMN1; SMN2HTR3E | |
| SCHEMBL27940445 | 0.80 | KCNH2 (0.55) | ALDH1A1LMNAMAPTALOX12SMN1; SMN2 | |
| SCHEMBL8717879 | 0.79 | AKR1C3 (0.54) | ALDH1A1LMNAMAPTSMN1; SMN2HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237406-B1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2019-02-06 | — | — | EP | disclosed |
| US-9314538-B2 | Nucleic acid molecules encoding antibody drug conjugates (ADC) that bind to 191P4D12 proteins | AGENSYS, INC. (US) | 2016-04-19 | — | — | US | disclosed |