Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
| ▸ | C1S | P09871 | 1/20 | 0.45 |
| ▸ | BPTF | Q12830 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.44 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20699709 | 0.85 | BPTF (0.54) | SMN1; SMN2HTTSCDC1SBPTF | |
| SCHEMBL10373948 | 0.85 | BPTF (0.54) | SMN1; SMN2HTTSCDC1SBPTF | |
| SCHEMBL20140813 | 0.82 | TSHR (0.38) | SMN1; SMN2HTTMEN1KMT2APOLB | |
| SCHEMBL20708552 | 0.81 | ALDH1A1 (0.60) | SMN1; SMN2HTTLMNAMAPTCYP1A2 | |
| SCHEMBL23222244 | 0.79 | DRD2 (0.56) | MEN1KMT2ALMNAMAPTTSHR | |
| SCHEMBL11889954 | 0.79 | ADRB1 (0.57) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL4052281 | 0.79 | AKR1C3 (0.52) | SMN1; SMN2MEN1KMT2ALMNAMAPT | |
| SCHEMBL2319884 | 0.79 | ALDH1A1 (0.60) | SMN1; SMN2HTTMEN1KMT2APOLB | |
| SCHEMBL298844 | 0.78 | ALDH1A1 (0.57) | SMN1; SMN2HTTMEN1KMT2APOLB | |
| SCHEMBL255378 | 0.77 | ALDH1A1 (0.52) | SMN1; SMN2HTTC1SBPTFMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532124-B1 | Use of nitrile derivatives as medicament. | ASTRAZENECA AB (SE) | 2006-07-19 | — | — | EP | disclosed |