Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | HPN | P05981 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19392447 | 0.74 | ACHE (0.53) | ACHE | |
| SCHEMBL20709296 | 0.73 | KMT2A (0.39) | SMN1; SMN2GAAHPGDRAB9ANPC1 | |
| SCHEMBL20709269 | 0.73 | SMN1; SMN2 (0.39) | SMN1; SMN2GAAHPGDRAB9ANPC1 | |
| SCHEMBL20709267 | 0.69 | KEAP1 (0.46) | SMN1; SMN2GAAHPGDACHERAB9A | |
| SCHEMBL20709254 | 0.69 | SMN1; SMN2 (0.40) | SMN1; SMN2GAAHPGDRAB9ANPC1 | |
| SCHEMBL78135 | 0.68 | ALDH1A1 (0.50) | SMN1; SMN2GAAHPGDACHERAB9A | |
| SCHEMBL23587447 | 0.67 | ESR1 (0.49) | HPGDACHEKEAP1NFE2L2CNR2 | |
| SCHEMBL13742741 | 0.66 | ESR1 (0.41) | ACHETSHRLMNA | |
| SCHEMBL22059363 | 0.66 | HPGD (0.42) | SMN1; SMN2GAAHPGDRAB9ANPC1 | |
| SCHEMBL19392429 | 0.64 | MAPT (0.53) | SMN1; SMN2GAARAB9ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077372-B1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA HOLDING BV (NL) | 2019-02-06 | — | — | EP | disclosed |