Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20709269 | 0.73 | SMN1; SMN2 (0.39) | KMT2ASMN1; SMN2LMNARAB9ANPC1 | |
| SCHEMBL20709259 | 0.73 | SMN1; SMN2 (0.40) | KMT2ASMN1; SMN2LMNACRHBPCRHR2 | |
| SCHEMBL20179130 | 0.69 | HDAC1 (0.55) | RAB9ANPC1HPGDALDH1A1MAPT | |
| SCHEMBL5918492 | 0.69 | RIPK1 (0.46) | — | |
| SCHEMBL20179330 | 0.67 | ALDH1A1 (0.52) | KMT2ASMN1; SMN2RAB9ANPC1HPGD | |
| SCHEMBL20709267 | 0.67 | KEAP1 (0.46) | KMT2ASMN1; SMN2LMNARAB9ANPC1 | |
| SCHEMBL24533708 | 0.65 | GRIA4 (0.38) | LMNACYP2D6GRIN2B | |
| SCHEMBL507696 | 0.65 | HRH3 (0.39) | — | |
| SCHEMBL28429831 | 0.64 | RIPK1 (0.39) | KMT2ASMN1; SMN2LMNAHPGDALDH1A1 | |
| SCHEMBL21386360 | 0.64 | SRC (0.52) | KMT2AATMSMN1; SMN2LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3077372-B1 | ROR GAMMA (RORY) MODULATORS | LEAD PHARMA HOLDING BV (NL) | 2019-02-06 | — | — | EP | disclosed |