Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681992 | 0.90 | HDAC8 (0.42) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL9683129 | 0.90 | MAPT (0.47) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL11569274 | 0.84 | ALDH1A1 (0.49) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL11274390 | 0.83 | PKM (0.52) | MAPTAPPALDH1A1SMN1; SMN2PKM | |
| SCHEMBL9683512 | 0.81 | TP53 (0.46) | TSHRALDH1A1GAATP53 | |
| SCHEMBL20715674 | 0.81 | HDAC8 (0.42) | MAPTL3MBTL1MEN1KMT2AHDAC8 | |
| SCHEMBL16044561 | 0.81 | AGER (0.56) | MAPTL3MBTL1MEN1KMT2AAGER | |
| SCHEMBL9681871 | 0.81 | MAPT (0.43) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL9683493 | 0.80 | MEN1 (0.59) | MAPTL3MBTL1MEN1KMT2ATDP1 | |
| SCHEMBL9683167 | 0.80 | HTT (0.51) | MAPTL3MBTL1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5128359-A | Benzimidazole and azabenzimidazole derivatives which are thromboxane receptor antagonists, their methods of preparation | LABORATOIRES UPSA (FR) | 1992-07-07 | — | — | US | disclosed |
| US-5124336-A | Cardiovascular disorders | LABORATOIRES UPSA (FR) | 1992-06-23 | — | — | US | disclosed |