SCHEMBL20715848

SCHEMBL20715848

CSC(=O)NC[C@@H](NC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccc(C(N)=O)cc1)C(=O)N[C@@H](CCCCN)C(=O)NC(C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)C(C)O

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 8/20 0.46
▸ NPY5R Q15761 7/20 0.46
▸ NPY1R P25929 6/20 0.46
▸ NPY2R P49146 5/20 0.42
▸ IL23R Q5VWK5 3/20 0.41
▸ KISS1R Q969F8 3/20 0.41
▸ NPBWR1 P48145 1/20 0.40
▸ GRIA1 P42261 1/20 0.38
▸ GHSR Q92847 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19234644 0.92 KISS1R (0.45) NPY4RNPY5RNPY1RNPY2RKISS1R
SCHEMBL24340682 0.89 NPY4R (0.44) NPY4RNPY5RNPY1RNPY2RIL23R
SCHEMBL24324975 0.86 NPY4R (0.45) NPY4RNPY5RNPY1RNPY2RIL23R
SCHEMBL24324995 0.85 OPRM1 (0.41) NPY4RNPY5RNPY1RNPY2RIL23R
SCHEMBL20715782 0.84 OPRM1 (0.51) NPY4RNPY5RNPY1RNPY2RIL23R
SCHEMBL20715847 0.84 OPRM1 (0.51) NPY4RNPY5RNPY1RNPY2RIL23R
SCHEMBL24325240 0.83 IL23R (0.41) NPY4RNPY5RNPY1RNPY2RIL23R
SCHEMBL20715788 0.83 NPY4R (0.45) NPY4RNPY5RNPY1RNPY2RIL23R
SCHEMBL20715581 0.82 OPRM1 (0.51) NPY4RNPY5RNPY1RNPY2RIL23R
SCHEMBL20715939 0.79 KISS1R (0.45) NPY4RNPY5RNPY1RNPY2RKISS1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11279732-B2 Somatostatin receptor antagonist compounds and methods of using the same CDRD VENTURES INC. (CA) 2022-03-22 — — US disclosed
US-20190040102-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME CDRD VENTURES INC. (CA) 2019-02-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11279732-B2 Somatostatin receptor antagonist compounds and methods of using the same GPR119, SSTR5, SSTR2 NPY4R 31/4885NPY5R 24/4885NPY1R 21/4885
US-20190040102-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME GPR119, SSTR5, SSTR2 NPY4R 31/4885NPY5R 24/4885NPY1R 21/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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