SCHEMBL20723646

SCHEMBL20723646

Nc1ccccc1S(=O)(=O)c1ccc(O)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTR6 P50406 2/20 0.71
▸ GAA P10253 5/20 0.63
▸ CA9 Q16790 4/20 0.50
▸ CA12 O43570 3/20 0.50
▸ CA1 P00915 3/20 0.50
▸ CA2 P00918 3/20 0.50
▸ CA4 P22748 2/20 0.50
▸ CYP2C9 P11712 1/20 0.50
▸ CA6 P23280 1/20 0.50
▸ CA5A P35218 1/20 0.50
▸ CA7 P43166 1/20 0.50
▸ CA14 Q9ULX7 1/20 0.50
▸ CA5B Q9Y2D0 1/20 0.50
▸ POLB P06746 2/20 0.49
▸ GFER P55789 1/20 0.49
▸ HKDC1 Q2TB90 1/20 0.45
▸ LMNA P02545 1/20 0.43
▸ PKM P14618 2/20 0.43
▸ ENPP2 Q13822 1/20 0.42
▸ KDM4E B2RXH2 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11264693 0.86 GAA (0.57) HTR6GAACA9CA12CA1
SCHEMBL34558 0.84 HTR6 (0.77) HTR6GAACA9CA12CA1
SCHEMBL30751995 0.84 HTR6 (1.00) HTR6GAACA9CA12CA1
SCHEMBL395274 0.84 HTR6 (1.00) HTR6GAACA9CA12CA1
SCHEMBL5676916 0.81 CA2 (0.68) HTR6GAACA9CA12CA1
SCHEMBL9464499 0.81 HTR6 (0.71) HTR6GAACA9CA12CA1
SCHEMBL2004711 0.81 HTR6 (0.71) HTR6GAACA9CA12CA1
SCHEMBL29381324 0.80 GAA (0.61) HTR6GAACA9CA12CA1
SCHEMBL28164 0.80 GAA (0.61) HTR6GAACA9CA12CA1
Alcohol SCHEMBL27500513 0.79 HTR6 (0.62) HTR6GAACA9CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10973831-B2 Fluoropiperidine compounds as pure 5-HT 6 receptor antagonists SUVEN LIFE SCIENCES LIMITED (IN) 2021-04-13 — — US disclosed
EP-3649124-B1 FLUOROPIPERIDINE COMPOUNDS AS PURE 5-HT6 RECEPTOR ANTAGONISTS SUVEN LIFE SCIENCES LTD (IN) 2021-03-03 — — EP disclosed
US-20200155560-A1 FLUOROPIPERIDINE COMPOUNDS AS PURE 5-HT 6 RECEPTOR ANTAGONISTS SUVEN LIFE SCIENCES LIMITED (IN) 2020-05-21 — — US disclosed
EP-3649124-A1 FLUOROPIPERIDINE COMPOUNDS AS PURE 5-HT6 RECEPTOR ANTAGONISTS Suven Life Sciences Limited (IN) 2020-05-13 — — EP disclosed
WO-2019030641-A1 FLUOROPIPERIDINE COMPOUNDS AS PURE 5-HT6 RECEPTOR ANTAGONISTS SUVEN LIFE SCIENCES LIMITED (IN) 2019-02-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200155560-A1 FLUOROPIPERIDINE COMPOUNDS AS PURE 5-HT 6 RECEPTOR ANTAGONISTS HTR6, HTR5A, HTR1B HTR6 1/4885GAA 3728/4885CA9 4007/4885
US-10973831-B2 Fluoropiperidine compounds as pure 5-HT 6 receptor antagonists HTR6, HTR5A, HTR1B HTR6 1/4885GAA 3728/4885CA9 4007/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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