Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | APP | P05067 | 5/20 | 0.41 |
| ▸ | SNCA | P37840 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726347 | 0.87 | DHODH (0.38) | PGRMAPTAPPSNCAPDGFRB | |
| SCHEMBL20726382 | 0.81 | EGFR (0.48) | EGFRALDH1A1LRRK2KDRAR | |
| SCHEMBL20726502 | 0.78 | BRD4 (0.39) | MAPTEGFRMEN1ALDH1A1KMT2A | |
| SCHEMBL20726357 | 0.77 | BRD4 (0.40) | MAPTEGFRMEN1ALDH1A1KMT2A | |
| SCHEMBL20726495 | 0.76 | EGFR (0.35) | EGFRKDRBRD4PDPK1 | |
| SCHEMBL20726412 | 0.76 | PRKDC (0.43) | PDGFRBBRD4CSF1R | |
| SCHEMBL20726418 | 0.74 | PRKAB2 (0.32) | BRD4 | |
| SCHEMBL20726441 | 0.72 | EGFR (0.40) | MAPTEGFRPDGFRBMEN1KMT2A | |
| SCHEMBL20726384 | 0.72 | PDE3B (0.50) | EGFRKDRBRD4 | |
| SCHEMBL16815924 | 0.72 | DHODH (0.39) | MAPTAPPSNCAPDGFRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083611-B1 | OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES | SANOFI SA (FR) | 2019-02-13 | — | — | EP | disclosed |