Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.39 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20726381 | 0.81 | PGR (0.43) | EGFRLRRK2ALDH1A1KDRAR | |
| SCHEMBL20726502 | 0.77 | BRD4 (0.39) | EGFRCHEK1MAOAALDH1A1KDR | |
| SCHEMBL20726357 | 0.76 | BRD4 (0.40) | EGFRCHEK1ALDH1A1 | |
| SCHEMBL20726412 | 0.75 | PRKDC (0.43) | CHEK1 | |
| SCHEMBL20726495 | 0.75 | EGFR (0.35) | EGFRCHEK1KDR | |
| SCHEMBL20726384 | 0.71 | PDE3B (0.50) | EGFRKDR | |
| SCHEMBL20726441 | 0.71 | EGFR (0.40) | EGFRKDR | |
| SCHEMBL20726427 | 0.70 | BRD4 (0.42) | EGFRCHEK1MAOAKDR | |
| SCHEMBL20726393 | 0.69 | EGFR (0.39) | EGFRCHEK1KDR | |
| SCHEMBL20726451 | 0.69 | EGFR (0.39) | EGFRCHEK1WEE1LRRK2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083611-B1 | OXINDOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE IN THE TREATMENT OF AMPK-RELATED DISEASES | SANOFI SA (FR) | 2019-02-13 | — | — | EP | disclosed |