Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7829298 | 0.83 | ALDH1A1 (0.37) | ALDH1A1PKMMEN1KMT2AKDM4E | |
| SCHEMBL6371677 | 0.78 | DGAT1 (0.34) | ALDH1A1LMNAMMP8L3MBTL1 | |
| SCHEMBL8563162 | 0.78 | LMNA (0.32) | LMNA | |
| SCHEMBL1450701 | 0.74 | CYP4F2 (0.41) | ALDH1A1PKMMEN1KMT2AKDM4E | |
| SCHEMBL3364717 | 0.72 | CYP4F2 (0.40) | ALDH1A1PKMMEN1KMT2AKDM4E | |
| SCHEMBL28498240 | 0.72 | ALDH1A1 (0.39) | ALDH1A1PKMMEN1KMT2AKDM4E | |
| SCHEMBL16048 | 0.72 | CYP4F2 (0.40) | ALDH1A1PKMMEN1KMT2AKDM4E | |
| SCHEMBL8563175 | 0.72 | ALDH1A1 (0.38) | ALDH1A1HSD17B10TSHR | |
| SCHEMBL21693639 | 0.72 | DGAT1 (0.45) | LMNA | |
| SCHEMBL28492515 | 0.72 | ALDH1A1 (0.39) | ALDH1A1PKMMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117447355-B | Preparation method of milbelin intermediate | 南京威凯尔生物医药科技有限公司 | 2024-03-19 | — | — | CN | claimed |
| CN-119350171-A | Preparation method and application of minogabalin besylate intermediate | 北京斯利安药业有限公司 | 2025-01-24 | — | — | CN | disclosed |
| CN-117447355-B | Preparation method of milbelin intermediate | 南京威凯尔生物医药科技有限公司 | 2024-03-19 | — | — | CN | disclosed |
| CN-117447355-A | Preparation method of milbelin intermediate | 南京威凯尔生物医药科技有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-114402198-A | Impurity detection method for 2- ((1S,2S,3R,6S,8S) -2- (aminomethyl) tricyclo [4.2.1.03,8] nonane-2-yl) acetic acid benzene sulfonate or composition thereof | 四川海思科制药有限公司 | 2022-04-26 | — | — | CN | disclosed |
| WO-2021043117-A1 | IMPURITY DETECTION METHOD FOR 2-((1S,2S,3R,6S,8S)-2-(AMINOMETHYL)TRICYCLO[4.2.1.0 3,8]NONANE-2-YL)ACETATE BENZENESULFONATE OR COMPOSITION THEREOF | 四川海思科制药有限公司 | 2021-03-11 | — | — | WO | disclosed |
| US-7868022-B2 | 2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2011-01-11 | — | — | US | disclosed |
| US-7776882-B2 | 2-amino-3,4-dihydro-quinoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-17 | — | — | US | disclosed |
| US-20080194624-A1 | 2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-14 | — | — | US | disclosed |
| US-20070232642-A1 | 2-AMINO-3,4-DIHYDRO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2007-10-04 | — | — | US | disclosed |
| WO-2007092846-A2 | 2-AMINO-3,4-DIHYDRO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE) | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-16 | — | — | WO | disclosed |
| WO-2007092854-A2 | 2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE) | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194624-A1 | 2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | BACE2, BACE1, PSEN2 | ALDH1A1 3765/4885PKM 4274/4885MEN1 992/4885 |
| US-20070232642-A1 | 2-AMINO-3,4-DIHYDRO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | BACE2, PSEN2, BACE1 | ALDH1A1 3248/4885PKM 4399/4885MEN1 1270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.