Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | CDK1 | P06493 | 3/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.36 |
| ▸ | CDK9 | P50750 | 3/20 | 0.36 |
| ▸ | CDK3 | Q00526 | 3/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754477 | 0.89 | WNT3A (0.40) | MAPK1GSK3BWNT3A | |
| SCHEMBL16754411 | 0.89 | GRM5 (0.42) | HCRTR1GSK3BABL1WNT3A | |
| SCHEMBL17778888 | 0.87 | PIM1 (0.38) | MAPK1ABL1WNT3A | |
| SCHEMBL17618513 | 0.87 | HCRTR1 (0.42) | HCRTR1MAPK1ABL1WNT3A | |
| SCHEMBL17778228 | 0.87 | GRM5 (0.37) | HCRTR1KDM4EHSD17B10ALDH1A1TSHR | |
| SCHEMBL16754401 | 0.87 | GRM5 (0.37) | HCRTR1KDM4EHSD17B10ALDH1A1TSHR | |
| SCHEMBL16754299 | 0.87 | GRM5 (0.37) | HCRTR1MAPK1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL16754282 | 0.86 | KARS1 (0.40) | MAPK1KDM4EHSD17B10ALDH1A1TSHR | |
| SCHEMBL17778323 | 0.86 | KARS1 (0.40) | MAPK1KDM4EHSD17B10ALDH1A1TSHR | |
| SCHEMBL16754551 | 0.86 | ROCK2 (0.38) | HCRTR1MAPK1KDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190048016-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2019-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190048016-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | HCRTR1 2441/4885MAPK1 1369/4885KDM4E 1291/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.