SCHEMBL20733435

SCHEMBL20733435

C=CC(=O)Cc1ccc(N(c2ccccc2)c2ccc(CC(=O)C=C)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.42
TSHR P16473 2/20 0.42
GLA P06280 1/20 0.42
AKT1 P31749 1/20 0.41
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
KCNH2 Q12809 1/20 0.41
NR3C1 P04150 1/20 0.40
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
AKR1B1 P15121 1/20 0.39
ABCC4 O15439 1/20 0.39
LMNA P02545 1/20 0.39
GAA P10253 1/20 0.39
PTGS1 P23219 1/20 0.39
HTT P42858 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.38
KDM4E B2RXH2 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14410123 1.00 ALDH1A1 (0.42) ALDH1A1TSHRGLAAKT1MEN1
SCHEMBL12395743 0.87 HCAR2 (0.42) ALDH1A1KMT2ANR3C1AKR1B1LMNA
SCHEMBL12751304 0.85 CRHBP (0.40) ALDH1A1TSHRGLAAKT1KMT2A
SCHEMBL13777807 0.84 ENPP2 (0.42) ALDH1A1TSHRNR3C1AKR1B1ABCC4
SCHEMBL13891773 0.84 RAB9A (0.41) ALDH1A1TSHRGLAMEN1KMT2A
SCHEMBL669706 0.83 CES1 (0.56) ALDH1A1TSHRAKT1MEN1KMT2A
SCHEMBL12395740 0.83 ALDH1A1 (0.39) ALDH1A1TSHRGLAMEN1KMT2A
SCHEMBL12571982 0.82 LMNA (0.38) ALDH1A1TSHRABCC4LMNAGAA
SCHEMBL14436821 0.82 ALDH1A1 (0.43) ALDH1A1TSHRMEN1KMT2AABCC4
Ammonia Solution, Strong SCHEMBL11111905 0.81 CES1 (0.54) ALDH1A1TSHRAKT1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10365569-B2 Electrophotographic photosensitive member, production method of electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2019-07-30 US disclosed
US-20190049867-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PRODUCTION METHOD OF ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2019-02-14 US disclosed