Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20734807 | 1.00 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2AKDM4CHTT | |
| SCHEMBL20734910 | 0.87 | MMP1 (0.48) | MEN1KMT2AKDM4CHTTNPC1 | |
| SCHEMBL24332981 | 0.87 | LMNA (0.40) | ALDH1A1MEN1KMT2AHTTNPC1 | |
| SCHEMBL20734933 | 0.87 | NPSR1 (0.40) | MEN1KMT2AKDM4CHTTPLA2G10 | |
| SCHEMBL20735047 | 0.87 | NPSR1 (0.40) | MEN1KMT2AKDM4CHTTPLA2G10 | |
| SCHEMBL21927104 | 0.85 | MEN1 (0.38) | MEN1KMT2AKDM4CHTTPLA2G10 | |
| SCHEMBL24333202 | 0.84 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AKDM4CHTT | |
| SCHEMBL20734853 | 0.84 | MAOB (0.50) | MEN1KMT2AKDM4CHTTNPC1 | |
| SCHEMBL20734851 | 0.84 | MAOB (0.50) | MEN1KMT2AKDM4CHTTNPC1 | |
| SCHEMBL20734891 | 0.83 | PLA2G10 (0.39) | ALDH1A1MEN1KMT2APLA2G10PLA2G5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11130733-B2 | 4-OXO-alkylated tetramic acid compound, preparation method and use thereof | BEIJING JOEKAI BIOTECH. LLC (CN) | 2021-09-28 | — | — | US | disclosed |
| US-20200361868-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, PREPARATION METHOD AND USE THEREOF | BEIJING JOEKAI BIOTECH. LLC (CN) | 2020-11-19 | — | — | US | disclosed |
| WO-2019029274-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND AND PREPARATION METHOD THEREFOR | 北京卓凯生物技术有限公司 | 2019-02-14 | — | — | WO | disclosed |
| WO-2019029273-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 北京卓凯生物技术有限公司 | 2019-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11130733-B2 | 4-OXO-alkylated tetramic acid compound, preparation method and use thereof | HTT, PARK7, PSEN1 | ALDH1A1 1056/4885MEN1 2261/4885KMT2A 921/4885 |
| US-20200361868-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, PREPARATION METHOD AND USE THEREOF | HTT, PARK7, PSEN1 | ALDH1A1 1056/4885MEN1 2261/4885KMT2A 921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.