Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20734851 | 1.00 | MAOB (0.50) | MAOBKMT2AARMEN1KDM4C | |
| SCHEMBL20734933 | 0.84 | NPSR1 (0.40) | MAOBKMT2AMEN1KDM4CHRH3 | |
| SCHEMBL20734808 | 0.84 | ALDH1A1 (0.44) | KMT2AARMEN1KDM4CHRH3 | |
| SCHEMBL20735047 | 0.84 | NPSR1 (0.40) | MAOBKMT2AMEN1KDM4CHRH3 | |
| SCHEMBL20734807 | 0.84 | ALDH1A1 (0.44) | KMT2AARMEN1KDM4CHRH3 | |
| SCHEMBL20734910 | 0.81 | MMP1 (0.48) | MAOBKMT2AMEN1KDM4CHRH3 | |
| SCHEMBL21927104 | 0.81 | MEN1 (0.38) | MAOBKMT2AMEN1KDM4CHRH3 | |
| SCHEMBL20734809 | 0.80 | MMP2 (0.46) | KMT2AMEN1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20734907 | 0.79 | ALOX5 (0.42) | MAOBKMT2AMEN1KDM4CHRH3 | |
| SCHEMBL20734947 | 0.78 | HRH3 (0.47) | KMT2AMEN1KDM4CHRH3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332440-B2 | 4-oxo-alkylated tetramic acid compound, and preparation method thereof | BEIJING JOEKAI BIOTECH. LLC (CN) | 2022-05-17 | — | — | US | disclosed |
| US-20200181081-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, AND PREPARATION METHOD THEREOF | BEIJING JOEKAI BIOTECH. LLC (CN) | 2020-06-11 | — | — | US | disclosed |
| WO-2019029274-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND AND PREPARATION METHOD THEREFOR | 北京卓凯生物技术有限公司 | 2019-02-14 | — | — | WO | disclosed |
| WO-2019029273-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 北京卓凯生物技术有限公司 | 2019-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11332440-B2 | 4-oxo-alkylated tetramic acid compound, and preparation method thereof | PSEN1, PSEN2, APP | MAOB 425/4885KMT2A 1871/4885AR 1782/4885 |
| US-20200181081-A1 | 4-OXO-ALKYLATED TETRAMIC ACID COMPOUND, AND PREPARATION METHOD THEREOF | PSEN1, PSEN2, APP | MAOB 425/4885KMT2A 1871/4885AR 1782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.