Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | CASP1 | P29466 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | CASP7 | P55210 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24455409 | 0.83 | RORC (0.36) | RORC | |
| SCHEMBL22190717 | 0.79 | CYP1A2 (0.39) | CYP1A2ALDH1A1CASP1HSD17B10CASP7 | |
| SCHEMBL20740567 | 0.79 | CDK5 (0.42) | MTORPIK3CAALDH1A1SMN1; SMN2 | |
| SCHEMBL17168775 | 0.73 | TYRO3 (0.41) | ADORA2BMTORALDH1A1MEN1KMT2A | |
| SCHEMBL17168761 | 0.72 | RORC (0.34) | RORC | |
| SCHEMBL17168858 | 0.70 | RORC (0.59) | RORC | |
| SCHEMBL4825502 | 0.70 | CDK4 (0.57) | — | |
| SCHEMBL21090442 | 0.69 | RORC (0.44) | RORC | |
| SCHEMBL17168862 | 0.69 | RORC (0.60) | RORCNPC1MAPT | |
| SCHEMBL1782345 | 0.69 | USP1 (0.43) | MTORMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3418280-B1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INT (DE) | 2023-07-12 | — | — | EP | disclosed |
| EP-3131902-B1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INT (DE) | 2019-06-12 | — | — | EP | disclosed |
| US-20180022749-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INT (DE) | 2018-01-25 | — | — | US | disclosed |
| US-20180022749-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INT (DE) | 2018-01-25 | — | — | US | disclosed |
| US-9598415-B2 | Compounds as modulators of RORγ | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-03-21 | — | — | US | disclosed |
| US-9598415-B2 | Compounds as modulators of RORγ | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-03-21 | — | — | US | disclosed |
| US-20170008894-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INT (DE) | 2017-01-12 | — | — | US | disclosed |
| US-20170008894-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INT (DE) | 2017-01-12 | — | — | US | disclosed |
| US-20160075706-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INT (DE) | 2016-03-17 | — | — | US | disclosed |
| US-9242989-B2 | Compounds as modulators of RORγ | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-01-26 | — | — | US | disclosed |
| US-9242989-B2 | Compounds as modulators of RORγ | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-01-26 | — | — | US | disclosed |
| WO-2015160654-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-22 | — | — | WO | disclosed |
| US-20150291607-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-15 | — | — | US | disclosed |
| US-20150291607-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180022749-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | RORB, RORC, RORA | ADORA2B 1701/4885MTOR 1966/4885PIK3CA 2141/4885 |
| US-20170008894-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | RORB, RORC, RORA | ADORA2B 1701/4885MTOR 1966/4885PIK3CA 2141/4885 |
| US-20150291607-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | RORB, RORC, RORA | ADORA2B 1701/4885MTOR 1966/4885PIK3CA 2141/4885 |
| US-20160075706-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | RORB, RORC, RORA | ADORA2B 1701/4885MTOR 1966/4885PIK3CA 2141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.